Cargando…

ROR1 is upregulated in endometrial cancer and represents a novel therapeutic target

ROR1 and ROR2 are receptor tyrosine kinases with altered expression in a range of cancers. Silencing ROR1 or ROR2 in different tumour types has been shown to inhibit proliferation and decrease metastatic potential. The aim of this study was to investigate the role of ROR1 and ROR2 in endometrial can...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Dongli, Gunther, Kate, Enriquez, Luis A., Daniels, Benjamin, O’Mara, Tracy A., Tang, Katrina, Spurdle, Amanda B., Ford, Caroline E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431863/ https://www.ncbi.nlm.nih.gov/pubmed/32807831 http://dx.doi.org/10.1038/s41598-020-70924-z

Ejemplares similares

Author Correction: ROR1 is upregulated in endometrial cancer and represents a novel therapeutic target
por: Liu, Dongli, et al.
Publicado: (2022)

ROR2 Is Epigenetically Regulated in Endometrial Cancer
por: Liu, Dongli, et al.
Publicado: (2021)

ROR1 and ROR2 expression in pancreatic cancer
por: Liu, Dongli, et al.
Publicado: (2021)

Meta-analysis of gene expression studies in endometrial cancer identifies gene expression profiles associated with aggressive disease and patient outcome
por: O’Mara, Tracy A., et al.
Publicado: (2016)

Analysis of Promoter-Associated Chromatin Interactions Reveals Biologically Relevant Candidate Target Genes at Endometrial Cancer Risk Loci
por: O’Mara, Tracy A., et al.
Publicado: (2019)

The Anti-ROR1 Monoclonal Antibody Zilovertamab Inhibits the Proliferation of Ovarian and Endometrial Cancer Cells
por: Liu, Dongli, et al.
Publicado: (2022)

Assessing the Role of Selenium in Endometrial Cancer Risk: A Mendelian Randomization Study
por: Kho, Pik Fang, et al.
Publicado: (2019)

Splicing annotation of endometrial cancer GWAS risk loci reveals potentially causal variants and supports a role for NF1 and SKAP1 as susceptibility genes
por: Canson, Daffodil M., et al.
Publicado: (2023)

Endometrial cancer risk and survival by tumor MMR status
por: Nagle, Christina M., et al.
Publicado: (2018)

Co-existence of leiomyomas, adenomyosis and endometriosis in women with endometrial cancer
por: Johnatty, Sharon E., et al.
Publicado: (2020)

Tumor Signature Analysis Implicates Hereditary Cancer Genes in Endometrial Cancer Development
por: Kondrashova, Olga, et al.
Publicado: (2021)

The Association of CYP19A1 Variation with Circulating Estradiol and Aromatase Inhibitor Outcome: Can CYP19A1 Variants Be Used to Predict Treatment Efficacy?
por: Glubb, Dylan M., et al.
Publicado: (2017)

Pan-Tissue and -Cancer Analysis of ROR1 and ROR2 Transcript Variants Identify Novel Functional Significance for an Alternative Splice Variant of ROR1
por: John, Miya, et al.
Publicado: (2022)

ECGene: A Literature‐Based Knowledgebase of Endometrial Cancer Genes
por: Zhao, Min, et al.
Publicado: (2016)

Polygenic risk score opportunities for early detection and prevention strategies in endometrial cancer
por: O’Mara, Tracy A., et al.
Publicado: (2020)

Silencing ROR1 and ROR2 inhibits invasion and adhesion in an organotypic model of ovarian cancer metastasis
por: Henry, Claire, et al.
Publicado: (2017)

10 Years of GWAS discovery in endometrial cancer: Aetiology, function and translation
por: Wang, Xuemin, et al.
Publicado: (2022)

Dietary Factors and Endometrial Cancer Risk: A Mendelian Randomization Study
por: Wang, Xuemin, et al.
Publicado: (2023)

Multi-tissue transcriptome-wide association study identifies eight candidate genes and tissue-specific gene expression underlying endometrial cancer susceptibility
por: Kho, Pik Fang, et al.
Publicado: (2021)

The Role of ROR1 in Chemoresistance and EMT in Endometrial Cancer Cells
por: Lee, Kyung-Jun, et al.
Publicado: (2023)

The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability
por: Russell, Holly, et al.
Publicado: (2020)

ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer
por: Wang, Junjian, et al.
Publicado: (2016)

Migration and invasion is inhibited by silencing ROR1 and ROR2 in chemoresistant ovarian cancer
por: Henry, C E, et al.
Publicado: (2016)

Correction to: The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability
por: Russell, Holly, et al.
Publicado: (2021)

Correction to: Migration and invasion is inhibited by silencing ROR1 and ROR2 in chemoresistant ovarian cancer
por: Henry, C. E., et al.
Publicado: (2022)

Targeting the ROR1 and ROR2 receptors in epithelial ovarian cancer inhibits cell migration and invasion
por: Henry, Claire, et al.
Publicado: (2015)

Multi-trait genome-wide association study identifies a novel endometrial cancer risk locus that associates with testosterone levels
por: Wang, Xuemin, et al.
Publicado: (2023)

Digoxin, an Overlooked Agonist of RORγ/RORγT
por: Karaś, Kaja, et al.
Publicado: (2019)

Distinct Patterns of Stromal and Tumor Expression of ROR1 and ROR2 in Histological Subtypes of Epithelial Ovarian Cancer()
por: Henry, CE, et al.
Publicado: (2017)

Acid ceramidase is upregulated in AML and represents a novel therapeutic target
por: Tan, Su-Fern, et al.
Publicado: (2016)

The therapeutic potential of RORγ modulators in the treatment of human disease
por: Chang, Mi Ra, et al.
Publicado: (2012)

A genome-wide association study to identify genetic markers associated with endometrial cancer grade
por: O’Mara, T, et al.
Publicado: (2012)

MeCP2 duplication causes hyperandrogenism by upregulating LHCGR and downregulating RORα
por: Wang, Yu-Meng, et al.
Publicado: (2021)

MIR-379-5p Expression in Endometrial Cancer and Its Correlation with ROR1 Expression
por: Mosaada, Hala, et al.
Publicado: (2023)

Associations between Genetically Predicted Circulating Protein Concentrations and Endometrial Cancer Risk
por: Zhu, Jingjing, et al.
Publicado: (2021)

Body Fat Distribution and Risk of Breast, Endometrial, and Ovarian Cancer: A Two-Sample Mendelian Randomization Study
por: Freuer, Dennis, et al.
Publicado: (2021)

RORα and RORγ expression inversely correlates with human melanoma progression
por: Brożyna, Anna A., et al.
Publicado: (2016)

The WNT/ROR Pathway in Cancer: From Signaling to Therapeutic Intervention
por: Menck, Kerstin, et al.
Publicado: (2021)

Twist promotes tumor metastasis in basal-like breast cancer by transcriptionally upregulating ROR1
por: Cao, Jingying, et al.
Publicado: (2018)

Child and adult adiposity and subtype-specific endometrial cancer risk: a multivariable Mendelian randomisation study
por: Kennedy, Oliver J., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fee36739ppshjeu2tjm1jqubao