Early Life Oxidative Stress and Long-Lasting Cardiovascular Effects on Offspring Conceived by Assisted Reproductive Technologies: A Review

Assisted reproductive technology (ART) has rapidly developed and is now widely practised worldwide. Both the characteristics of ART (handling gametes/embryos in vitro) and the infertility backgrounds of ART parents (such as infertility diseases and unfavourable lifestyles or diets) could cause incre...

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Autores principales: Yang, Huixia, Kuhn, Christina, Kolben, Thomas, Ma, Zhi, Lin, Peng, Mahner, Sven, Jeschke, Udo, von Schönfeldt, Viktoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432066/
https://www.ncbi.nlm.nih.gov/pubmed/32707756
http://dx.doi.org/10.3390/ijms21155175
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author Yang, Huixia
Kuhn, Christina
Kolben, Thomas
Ma, Zhi
Lin, Peng
Mahner, Sven
Jeschke, Udo
von Schönfeldt, Viktoria
author_facet Yang, Huixia
Kuhn, Christina
Kolben, Thomas
Ma, Zhi
Lin, Peng
Mahner, Sven
Jeschke, Udo
von Schönfeldt, Viktoria
author_sort Yang, Huixia
collection PubMed
description Assisted reproductive technology (ART) has rapidly developed and is now widely practised worldwide. Both the characteristics of ART (handling gametes/embryos in vitro) and the infertility backgrounds of ART parents (such as infertility diseases and unfavourable lifestyles or diets) could cause increased oxidative stress (OS) that may exert adverse influences on gametogenesis, fertilisation, and foetation, even causing a long-lasting influence on the offspring. For these reasons, the safety of ART needs to be closely examined. In this review, from an ART safety standpoint, the origins of OS are reviewed, and the long-lasting cardiovascular effects and potential mechanisms of OS on the offspring are discussed.
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spelling pubmed-74320662020-08-24 Early Life Oxidative Stress and Long-Lasting Cardiovascular Effects on Offspring Conceived by Assisted Reproductive Technologies: A Review Yang, Huixia Kuhn, Christina Kolben, Thomas Ma, Zhi Lin, Peng Mahner, Sven Jeschke, Udo von Schönfeldt, Viktoria Int J Mol Sci Review Assisted reproductive technology (ART) has rapidly developed and is now widely practised worldwide. Both the characteristics of ART (handling gametes/embryos in vitro) and the infertility backgrounds of ART parents (such as infertility diseases and unfavourable lifestyles or diets) could cause increased oxidative stress (OS) that may exert adverse influences on gametogenesis, fertilisation, and foetation, even causing a long-lasting influence on the offspring. For these reasons, the safety of ART needs to be closely examined. In this review, from an ART safety standpoint, the origins of OS are reviewed, and the long-lasting cardiovascular effects and potential mechanisms of OS on the offspring are discussed. MDPI 2020-07-22 /pmc/articles/PMC7432066/ /pubmed/32707756 http://dx.doi.org/10.3390/ijms21155175 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yang, Huixia
Kuhn, Christina
Kolben, Thomas
Ma, Zhi
Lin, Peng
Mahner, Sven
Jeschke, Udo
von Schönfeldt, Viktoria
Early Life Oxidative Stress and Long-Lasting Cardiovascular Effects on Offspring Conceived by Assisted Reproductive Technologies: A Review
title Early Life Oxidative Stress and Long-Lasting Cardiovascular Effects on Offspring Conceived by Assisted Reproductive Technologies: A Review
title_full Early Life Oxidative Stress and Long-Lasting Cardiovascular Effects on Offspring Conceived by Assisted Reproductive Technologies: A Review
title_fullStr Early Life Oxidative Stress and Long-Lasting Cardiovascular Effects on Offspring Conceived by Assisted Reproductive Technologies: A Review
title_full_unstemmed Early Life Oxidative Stress and Long-Lasting Cardiovascular Effects on Offspring Conceived by Assisted Reproductive Technologies: A Review
title_short Early Life Oxidative Stress and Long-Lasting Cardiovascular Effects on Offspring Conceived by Assisted Reproductive Technologies: A Review
title_sort early life oxidative stress and long-lasting cardiovascular effects on offspring conceived by assisted reproductive technologies: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432066/
https://www.ncbi.nlm.nih.gov/pubmed/32707756
http://dx.doi.org/10.3390/ijms21155175
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