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Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS)

Few studies have assessed the accuracy of self-reported questionnaires to determine smoking habits relative to urinary biomarkers. This study investigated urinary cotinine cut-off concentrations distinguishing active, passive and non-smokers among pregnant women who participated in the Japan Environ...

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Autores principales: Nishihama, Yukiko, Nakayama, Shoji F., Tabuchi, Takahiro, Isobe, Tomohiko, Jung, Chau-Ren, Iwai-Shimada, Miyuki, Kobayashi, Yayoi, Michikawa, Takehiro, Sekiyama, Makiko, Taniguchi, Yu, Nitta, Hiroshi, Yamazaki, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432074/
https://www.ncbi.nlm.nih.gov/pubmed/32751831
http://dx.doi.org/10.3390/ijerph17155537
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author Nishihama, Yukiko
Nakayama, Shoji F.
Tabuchi, Takahiro
Isobe, Tomohiko
Jung, Chau-Ren
Iwai-Shimada, Miyuki
Kobayashi, Yayoi
Michikawa, Takehiro
Sekiyama, Makiko
Taniguchi, Yu
Nitta, Hiroshi
Yamazaki, Shin
author_facet Nishihama, Yukiko
Nakayama, Shoji F.
Tabuchi, Takahiro
Isobe, Tomohiko
Jung, Chau-Ren
Iwai-Shimada, Miyuki
Kobayashi, Yayoi
Michikawa, Takehiro
Sekiyama, Makiko
Taniguchi, Yu
Nitta, Hiroshi
Yamazaki, Shin
author_sort Nishihama, Yukiko
collection PubMed
description Few studies have assessed the accuracy of self-reported questionnaires to determine smoking habits relative to urinary biomarkers. This study investigated urinary cotinine cut-off concentrations distinguishing active, passive and non-smokers among pregnant women who participated in the Japan Environment and Children’s Study, a nationwide birth cohort study. Pregnant participants with measured urinary cotinine concentrations (UCCs) and who completed self-reported questionnaires on smoking status were included (n = 89,895). The cut-off values (COVs) for active and passive smokers were calculated by fitting mixed normal distribution functions to UCCs. The sensitivity and specificity of the questionnaires were subsequently evaluated. The median (interquartile range) UCC was 0.24 (0.083–0.96) µg/g-creatinine, with the detection rate of 89%. The COV for distinguishing active smokers from passive and non-smokers was 36.8 µg/g-creatinine. When this COV was considered to represent the true condition, the questionnaire had a sensitivity of 0.523, a specificity of 0.998, a positive predictive value (PPV) of 0.967 and a negative predictive value (NPV) of 0.957. The COV for distinguishing passive smokers from non-smokers was 0.31 µg/g-creatinine, with the questionnaire having a sensitivity of 0.222, a specificity of 0.977, a PPV of 0.868 and an NPV of 0.644. As many as 78% of passive smokers might be misclassified as non-smokers.
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spelling pubmed-74320742020-08-24 Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS) Nishihama, Yukiko Nakayama, Shoji F. Tabuchi, Takahiro Isobe, Tomohiko Jung, Chau-Ren Iwai-Shimada, Miyuki Kobayashi, Yayoi Michikawa, Takehiro Sekiyama, Makiko Taniguchi, Yu Nitta, Hiroshi Yamazaki, Shin Int J Environ Res Public Health Article Few studies have assessed the accuracy of self-reported questionnaires to determine smoking habits relative to urinary biomarkers. This study investigated urinary cotinine cut-off concentrations distinguishing active, passive and non-smokers among pregnant women who participated in the Japan Environment and Children’s Study, a nationwide birth cohort study. Pregnant participants with measured urinary cotinine concentrations (UCCs) and who completed self-reported questionnaires on smoking status were included (n = 89,895). The cut-off values (COVs) for active and passive smokers were calculated by fitting mixed normal distribution functions to UCCs. The sensitivity and specificity of the questionnaires were subsequently evaluated. The median (interquartile range) UCC was 0.24 (0.083–0.96) µg/g-creatinine, with the detection rate of 89%. The COV for distinguishing active smokers from passive and non-smokers was 36.8 µg/g-creatinine. When this COV was considered to represent the true condition, the questionnaire had a sensitivity of 0.523, a specificity of 0.998, a positive predictive value (PPV) of 0.967 and a negative predictive value (NPV) of 0.957. The COV for distinguishing passive smokers from non-smokers was 0.31 µg/g-creatinine, with the questionnaire having a sensitivity of 0.222, a specificity of 0.977, a PPV of 0.868 and an NPV of 0.644. As many as 78% of passive smokers might be misclassified as non-smokers. MDPI 2020-07-31 2020-08 /pmc/articles/PMC7432074/ /pubmed/32751831 http://dx.doi.org/10.3390/ijerph17155537 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nishihama, Yukiko
Nakayama, Shoji F.
Tabuchi, Takahiro
Isobe, Tomohiko
Jung, Chau-Ren
Iwai-Shimada, Miyuki
Kobayashi, Yayoi
Michikawa, Takehiro
Sekiyama, Makiko
Taniguchi, Yu
Nitta, Hiroshi
Yamazaki, Shin
Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS)
title Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS)
title_full Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS)
title_fullStr Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS)
title_full_unstemmed Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS)
title_short Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS)
title_sort determination of urinary cotinine cut-off concentrations for pregnant women in the japan environment and children’s study (jecs)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432074/
https://www.ncbi.nlm.nih.gov/pubmed/32751831
http://dx.doi.org/10.3390/ijerph17155537
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