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Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS)
Few studies have assessed the accuracy of self-reported questionnaires to determine smoking habits relative to urinary biomarkers. This study investigated urinary cotinine cut-off concentrations distinguishing active, passive and non-smokers among pregnant women who participated in the Japan Environ...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432074/ https://www.ncbi.nlm.nih.gov/pubmed/32751831 http://dx.doi.org/10.3390/ijerph17155537 |
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author | Nishihama, Yukiko Nakayama, Shoji F. Tabuchi, Takahiro Isobe, Tomohiko Jung, Chau-Ren Iwai-Shimada, Miyuki Kobayashi, Yayoi Michikawa, Takehiro Sekiyama, Makiko Taniguchi, Yu Nitta, Hiroshi Yamazaki, Shin |
author_facet | Nishihama, Yukiko Nakayama, Shoji F. Tabuchi, Takahiro Isobe, Tomohiko Jung, Chau-Ren Iwai-Shimada, Miyuki Kobayashi, Yayoi Michikawa, Takehiro Sekiyama, Makiko Taniguchi, Yu Nitta, Hiroshi Yamazaki, Shin |
author_sort | Nishihama, Yukiko |
collection | PubMed |
description | Few studies have assessed the accuracy of self-reported questionnaires to determine smoking habits relative to urinary biomarkers. This study investigated urinary cotinine cut-off concentrations distinguishing active, passive and non-smokers among pregnant women who participated in the Japan Environment and Children’s Study, a nationwide birth cohort study. Pregnant participants with measured urinary cotinine concentrations (UCCs) and who completed self-reported questionnaires on smoking status were included (n = 89,895). The cut-off values (COVs) for active and passive smokers were calculated by fitting mixed normal distribution functions to UCCs. The sensitivity and specificity of the questionnaires were subsequently evaluated. The median (interquartile range) UCC was 0.24 (0.083–0.96) µg/g-creatinine, with the detection rate of 89%. The COV for distinguishing active smokers from passive and non-smokers was 36.8 µg/g-creatinine. When this COV was considered to represent the true condition, the questionnaire had a sensitivity of 0.523, a specificity of 0.998, a positive predictive value (PPV) of 0.967 and a negative predictive value (NPV) of 0.957. The COV for distinguishing passive smokers from non-smokers was 0.31 µg/g-creatinine, with the questionnaire having a sensitivity of 0.222, a specificity of 0.977, a PPV of 0.868 and an NPV of 0.644. As many as 78% of passive smokers might be misclassified as non-smokers. |
format | Online Article Text |
id | pubmed-7432074 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74320742020-08-24 Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS) Nishihama, Yukiko Nakayama, Shoji F. Tabuchi, Takahiro Isobe, Tomohiko Jung, Chau-Ren Iwai-Shimada, Miyuki Kobayashi, Yayoi Michikawa, Takehiro Sekiyama, Makiko Taniguchi, Yu Nitta, Hiroshi Yamazaki, Shin Int J Environ Res Public Health Article Few studies have assessed the accuracy of self-reported questionnaires to determine smoking habits relative to urinary biomarkers. This study investigated urinary cotinine cut-off concentrations distinguishing active, passive and non-smokers among pregnant women who participated in the Japan Environment and Children’s Study, a nationwide birth cohort study. Pregnant participants with measured urinary cotinine concentrations (UCCs) and who completed self-reported questionnaires on smoking status were included (n = 89,895). The cut-off values (COVs) for active and passive smokers were calculated by fitting mixed normal distribution functions to UCCs. The sensitivity and specificity of the questionnaires were subsequently evaluated. The median (interquartile range) UCC was 0.24 (0.083–0.96) µg/g-creatinine, with the detection rate of 89%. The COV for distinguishing active smokers from passive and non-smokers was 36.8 µg/g-creatinine. When this COV was considered to represent the true condition, the questionnaire had a sensitivity of 0.523, a specificity of 0.998, a positive predictive value (PPV) of 0.967 and a negative predictive value (NPV) of 0.957. The COV for distinguishing passive smokers from non-smokers was 0.31 µg/g-creatinine, with the questionnaire having a sensitivity of 0.222, a specificity of 0.977, a PPV of 0.868 and an NPV of 0.644. As many as 78% of passive smokers might be misclassified as non-smokers. MDPI 2020-07-31 2020-08 /pmc/articles/PMC7432074/ /pubmed/32751831 http://dx.doi.org/10.3390/ijerph17155537 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nishihama, Yukiko Nakayama, Shoji F. Tabuchi, Takahiro Isobe, Tomohiko Jung, Chau-Ren Iwai-Shimada, Miyuki Kobayashi, Yayoi Michikawa, Takehiro Sekiyama, Makiko Taniguchi, Yu Nitta, Hiroshi Yamazaki, Shin Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS) |
title | Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS) |
title_full | Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS) |
title_fullStr | Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS) |
title_full_unstemmed | Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS) |
title_short | Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS) |
title_sort | determination of urinary cotinine cut-off concentrations for pregnant women in the japan environment and children’s study (jecs) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432074/ https://www.ncbi.nlm.nih.gov/pubmed/32751831 http://dx.doi.org/10.3390/ijerph17155537 |
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