Persistent Human KIT Receptor Signaling Disposes Murine Placenta to Premature Differentiation Resulting in Severely Disrupted Placental Structure and Functionality

Activating mutations in the human KIT receptor is known to drive severe hematopoietic disorders and tumor formation spanning various entities. The most common mutation is the substitution of aspartic acid at position 816 to valine (D816V), rendering the receptor constitutively active independent of...

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Detalles Bibliográficos
Autores principales: Kaiser, Franziska, Hartweg, Julia, Jansky, Selina, Pelusi, Natalie, Kubaczka, Caroline, Sharma, Neha, Nitsche, Dominik, Langkabel, Jan, Schorle, Hubert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432075/
https://www.ncbi.nlm.nih.gov/pubmed/32752102
http://dx.doi.org/10.3390/ijms21155503

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