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Flexible NAD(+) Binding in Deoxyhypusine Synthase Reflects the Dynamic Hypusine Modification of Translation Factor IF5A

The eukaryotic and archaeal translation factor IF5A requires a post-translational hypusine modification, which is catalyzed by deoxyhypusine synthase (DHS) at a single lysine residue of IF5A with NAD(+) and spermidine as cofactors, followed by hydroxylation to form hypusine. While human DHS catalyze...

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Detalles Bibliográficos
Autores principales:	Chen, Meirong, Gai, Zuoqi, Okada, Chiaki, Ye, Yuxin, Yu, Jian, Yao, Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432094/ https://www.ncbi.nlm.nih.gov/pubmed/32752130 http://dx.doi.org/10.3390/ijms21155509

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