Cargando…
Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases
An increasing number of reports suggests a significant involvement of the phosphoinositide (PI) cycle in cancer development and progression. Diacylglycerol kinases (DGKs) are very active in the PI cycle. They are a family of ten members that convert diacylglycerol (DAG) into phosphatidic acid (PA),...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432101/ https://www.ncbi.nlm.nih.gov/pubmed/32722576 http://dx.doi.org/10.3390/ijms21155297 |
_version_ | 1783571722056761344 |
---|---|
author | Fazio, Antonietta Owusu Obeng, Eric Rusciano, Isabella Marvi, Maria Vittoria Zoli, Matteo Mongiorgi, Sara Ramazzotti, Giulia Follo, Matilde Yung McCubrey, James A. Cocco, Lucio Manzoli, Lucia Ratti, Stefano |
author_facet | Fazio, Antonietta Owusu Obeng, Eric Rusciano, Isabella Marvi, Maria Vittoria Zoli, Matteo Mongiorgi, Sara Ramazzotti, Giulia Follo, Matilde Yung McCubrey, James A. Cocco, Lucio Manzoli, Lucia Ratti, Stefano |
author_sort | Fazio, Antonietta |
collection | PubMed |
description | An increasing number of reports suggests a significant involvement of the phosphoinositide (PI) cycle in cancer development and progression. Diacylglycerol kinases (DGKs) are very active in the PI cycle. They are a family of ten members that convert diacylglycerol (DAG) into phosphatidic acid (PA), two-second messengers with versatile cellular functions. Notably, some DGK isoforms, such as DGKα, have been reported to possess promising therapeutic potential in cancer therapy. However, further studies are needed in order to better comprehend their involvement in cancer. In this review, we highlight that DGKs are an essential component of the PI cycle that localize within several subcellular compartments, including the nucleus and plasma membrane, together with their PI substrates and that they are involved in mediating major cancer cell mechanisms such as growth and metastasis. DGKs control cancer cell survival, proliferation, and angiogenesis by regulating Akt/mTOR and MAPK/ERK pathways. In addition, some DGKs control cancer cell migration by regulating the activities of the Rho GTPases Rac1 and RhoA. |
format | Online Article Text |
id | pubmed-7432101 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74321012020-08-24 Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases Fazio, Antonietta Owusu Obeng, Eric Rusciano, Isabella Marvi, Maria Vittoria Zoli, Matteo Mongiorgi, Sara Ramazzotti, Giulia Follo, Matilde Yung McCubrey, James A. Cocco, Lucio Manzoli, Lucia Ratti, Stefano Int J Mol Sci Review An increasing number of reports suggests a significant involvement of the phosphoinositide (PI) cycle in cancer development and progression. Diacylglycerol kinases (DGKs) are very active in the PI cycle. They are a family of ten members that convert diacylglycerol (DAG) into phosphatidic acid (PA), two-second messengers with versatile cellular functions. Notably, some DGK isoforms, such as DGKα, have been reported to possess promising therapeutic potential in cancer therapy. However, further studies are needed in order to better comprehend their involvement in cancer. In this review, we highlight that DGKs are an essential component of the PI cycle that localize within several subcellular compartments, including the nucleus and plasma membrane, together with their PI substrates and that they are involved in mediating major cancer cell mechanisms such as growth and metastasis. DGKs control cancer cell survival, proliferation, and angiogenesis by regulating Akt/mTOR and MAPK/ERK pathways. In addition, some DGKs control cancer cell migration by regulating the activities of the Rho GTPases Rac1 and RhoA. MDPI 2020-07-26 /pmc/articles/PMC7432101/ /pubmed/32722576 http://dx.doi.org/10.3390/ijms21155297 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fazio, Antonietta Owusu Obeng, Eric Rusciano, Isabella Marvi, Maria Vittoria Zoli, Matteo Mongiorgi, Sara Ramazzotti, Giulia Follo, Matilde Yung McCubrey, James A. Cocco, Lucio Manzoli, Lucia Ratti, Stefano Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases |
title | Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases |
title_full | Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases |
title_fullStr | Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases |
title_full_unstemmed | Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases |
title_short | Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases |
title_sort | subcellular localization relevance and cancer-associated mechanisms of diacylglycerol kinases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432101/ https://www.ncbi.nlm.nih.gov/pubmed/32722576 http://dx.doi.org/10.3390/ijms21155297 |
work_keys_str_mv | AT fazioantonietta subcellularlocalizationrelevanceandcancerassociatedmechanismsofdiacylglycerolkinases AT owusuobengeric subcellularlocalizationrelevanceandcancerassociatedmechanismsofdiacylglycerolkinases AT ruscianoisabella subcellularlocalizationrelevanceandcancerassociatedmechanismsofdiacylglycerolkinases AT marvimariavittoria subcellularlocalizationrelevanceandcancerassociatedmechanismsofdiacylglycerolkinases AT zolimatteo subcellularlocalizationrelevanceandcancerassociatedmechanismsofdiacylglycerolkinases AT mongiorgisara subcellularlocalizationrelevanceandcancerassociatedmechanismsofdiacylglycerolkinases AT ramazzottigiulia subcellularlocalizationrelevanceandcancerassociatedmechanismsofdiacylglycerolkinases AT follomatildeyung subcellularlocalizationrelevanceandcancerassociatedmechanismsofdiacylglycerolkinases AT mccubreyjamesa subcellularlocalizationrelevanceandcancerassociatedmechanismsofdiacylglycerolkinases AT coccolucio subcellularlocalizationrelevanceandcancerassociatedmechanismsofdiacylglycerolkinases AT manzolilucia subcellularlocalizationrelevanceandcancerassociatedmechanismsofdiacylglycerolkinases AT rattistefano subcellularlocalizationrelevanceandcancerassociatedmechanismsofdiacylglycerolkinases |