Cargando…
Exploring associations of maternal sleep during periconceptional period with congenital heart disease in offspring
BACKGROUND: In general, the existing evidence points to a role for maternal sleep in pregnancy complications and fetal growth, however, little has been focused on birth defects. We aimed to explore the association between periconceptional poor sleep and the risk of congenital heart disease (CHD), an...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432175/ https://www.ncbi.nlm.nih.gov/pubmed/31206252 http://dx.doi.org/10.1002/bdr2.1536 |
_version_ | 1783571739461025792 |
---|---|
author | Zhao, Anda Zhao, Kena Xia, Yuanqing Yin, Yong Zhu, Jianzhen Hong, Haifa Li, Shenghui |
author_facet | Zhao, Anda Zhao, Kena Xia, Yuanqing Yin, Yong Zhu, Jianzhen Hong, Haifa Li, Shenghui |
author_sort | Zhao, Anda |
collection | PubMed |
description | BACKGROUND: In general, the existing evidence points to a role for maternal sleep in pregnancy complications and fetal growth, however, little has been focused on birth defects. We aimed to explore the association between periconceptional poor sleep and the risk of congenital heart disease (CHD), and to examine if daytime napping could to some extent change the association. METHODS: A case–control study was conducted in Shanghai Children's Medical Center, in which, a total of 524 cases (262 simple CHD vs. 262 severe CHD), along with 262 controls. RESULTS: In the multivariable logistic analysis, poor sleep could increase the risk of both simple CHD (OR = 2.486, 95% CI = 1.619–3.818) and severe CHD (OR = 1.950, 95% CI = 1.269–2.997), while routine daytime nap could decrease risk of simple CHD (OR = 0.634, 95% CI = 0.435–0.923). In the stratified analysis, the concurrence with routine daytime nap could weaken the risk of simple CHD caused by poor sleep (OR = 3.183, 95% CI: 1.830–5.537 decreased to OR = 2.236, 95% CI: 1.200–4.165). The examinations were repeated in ventricular septal defect and tetralogy of Fallot, and the established associations can be verified. Moreover, all these findings were also similarly observed in both propensity‐score‐adjusted and propensity‐score‐matched analyses. CONCLUSIONS: Poor maternal sleep around periconceptional period seems to be an independent risk factor for CHD. The concurrence with daytime nap could to some extent reduce the risk in simple CHD. The results individually and collectively put forward the importance of maternal sleep in embryonic heart development. |
format | Online Article Text |
id | pubmed-7432175 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74321752020-08-20 Exploring associations of maternal sleep during periconceptional period with congenital heart disease in offspring Zhao, Anda Zhao, Kena Xia, Yuanqing Yin, Yong Zhu, Jianzhen Hong, Haifa Li, Shenghui Birth Defects Res Original Articles BACKGROUND: In general, the existing evidence points to a role for maternal sleep in pregnancy complications and fetal growth, however, little has been focused on birth defects. We aimed to explore the association between periconceptional poor sleep and the risk of congenital heart disease (CHD), and to examine if daytime napping could to some extent change the association. METHODS: A case–control study was conducted in Shanghai Children's Medical Center, in which, a total of 524 cases (262 simple CHD vs. 262 severe CHD), along with 262 controls. RESULTS: In the multivariable logistic analysis, poor sleep could increase the risk of both simple CHD (OR = 2.486, 95% CI = 1.619–3.818) and severe CHD (OR = 1.950, 95% CI = 1.269–2.997), while routine daytime nap could decrease risk of simple CHD (OR = 0.634, 95% CI = 0.435–0.923). In the stratified analysis, the concurrence with routine daytime nap could weaken the risk of simple CHD caused by poor sleep (OR = 3.183, 95% CI: 1.830–5.537 decreased to OR = 2.236, 95% CI: 1.200–4.165). The examinations were repeated in ventricular septal defect and tetralogy of Fallot, and the established associations can be verified. Moreover, all these findings were also similarly observed in both propensity‐score‐adjusted and propensity‐score‐matched analyses. CONCLUSIONS: Poor maternal sleep around periconceptional period seems to be an independent risk factor for CHD. The concurrence with daytime nap could to some extent reduce the risk in simple CHD. The results individually and collectively put forward the importance of maternal sleep in embryonic heart development. John Wiley & Sons, Inc. 2019-06-17 2019-08-01 /pmc/articles/PMC7432175/ /pubmed/31206252 http://dx.doi.org/10.1002/bdr2.1536 Text en © 2019 The Authors. Birth Defects Research published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Zhao, Anda Zhao, Kena Xia, Yuanqing Yin, Yong Zhu, Jianzhen Hong, Haifa Li, Shenghui Exploring associations of maternal sleep during periconceptional period with congenital heart disease in offspring |
title | Exploring associations of maternal sleep during periconceptional period with congenital heart disease in offspring |
title_full | Exploring associations of maternal sleep during periconceptional period with congenital heart disease in offspring |
title_fullStr | Exploring associations of maternal sleep during periconceptional period with congenital heart disease in offspring |
title_full_unstemmed | Exploring associations of maternal sleep during periconceptional period with congenital heart disease in offspring |
title_short | Exploring associations of maternal sleep during periconceptional period with congenital heart disease in offspring |
title_sort | exploring associations of maternal sleep during periconceptional period with congenital heart disease in offspring |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432175/ https://www.ncbi.nlm.nih.gov/pubmed/31206252 http://dx.doi.org/10.1002/bdr2.1536 |
work_keys_str_mv | AT zhaoanda exploringassociationsofmaternalsleepduringpericonceptionalperiodwithcongenitalheartdiseaseinoffspring AT zhaokena exploringassociationsofmaternalsleepduringpericonceptionalperiodwithcongenitalheartdiseaseinoffspring AT xiayuanqing exploringassociationsofmaternalsleepduringpericonceptionalperiodwithcongenitalheartdiseaseinoffspring AT yinyong exploringassociationsofmaternalsleepduringpericonceptionalperiodwithcongenitalheartdiseaseinoffspring AT zhujianzhen exploringassociationsofmaternalsleepduringpericonceptionalperiodwithcongenitalheartdiseaseinoffspring AT honghaifa exploringassociationsofmaternalsleepduringpericonceptionalperiodwithcongenitalheartdiseaseinoffspring AT lishenghui exploringassociationsofmaternalsleepduringpericonceptionalperiodwithcongenitalheartdiseaseinoffspring |