Cargando…

Induction of Apoptosis by Coptisine in Hep3B Hepatocellular Carcinoma Cells through Activation of the ROS-Mediated JNK Signaling Pathway

Hepatocellular carcinoma (HCC) has a high mortality rate worldwide, and treatment is very limited due to its high recurrence and low diagnosis rate, and therefore there is an increasing need to develop more effective drugs to treat HCC. Coptisine is one of the isoquinoline alkaloids, and it has vari...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, So Young, Hwangbo, Hyun, Lee, Hyesook, Park, Cheol, Kim, Gi-Young, Moon, Sung-Kwon, Yun, Seok Joong, Kim, Wun-Jae, Cheong, Jaehun, Choi, Yung Hyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432186/ https://www.ncbi.nlm.nih.gov/pubmed/32752099 http://dx.doi.org/10.3390/ijms21155502

Ejemplares similares

Induction of Apoptosis by Isoalantolactone in Human Hepatocellular Carcinoma Hep3B Cells through Activation of the ROS-Dependent JNK Signaling Pathway
por: Kim, Min Yeong, et al.
Publicado: (2021)

ROS-Mediated Anti-Tumor Effect of Coptidis Rhizoma against Human Hepatocellular Carcinoma Hep3B Cells and Xenografts
por: Kim, So Young, et al.
Publicado: (2021)

Auranofin Enhances Sulforaphane-Mediated Apoptosis in Hepatocellular Carcinoma Hep3B Cells through Inactivation of the PI3K/Akt Signaling Pathway
por: Hwangbo, Hyun, et al.
Publicado: (2020)

Induction of apoptotic cell death in human bladder cancer cells by ethanol extract of Zanthoxylum schinifolium leaf, through ROS-dependent inactivation of the PI3K/Akt signaling pathway
por: Park, Cheol, et al.
Publicado: (2022)

Anti-Proliferative and Pro-Apoptotic Effects of Licochalcone A through ROS-Mediated Cell Cycle Arrest and Apoptosis in Human Bladder Cancer Cells
por: Hong, Su Hyun, et al.
Publicado: (2019)

Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential
por: Kim, So Young, et al.
Publicado: (2021)

Anti-Inflammatory Effect of Auranofin on Palmitic Acid and LPS-Induced Inflammatory Response by Modulating TLR4 and NOX4-Mediated NF-κB Signaling Pathway in RAW264.7 Macrophages
por: Hwangbo, Hyun, et al.
Publicado: (2021)

Auranofin Attenuates Non-Alcoholic Fatty Liver Disease by Suppressing Lipid Accumulation and NLRP3 Inflammasome-Mediated Hepatic Inflammation In Vivo and In Vitro
por: Hwangbo, Hyun, et al.
Publicado: (2020)

Ethanol Extract of Hizikia fusiforme Induces Apoptosis in B16F10 Mouse Melanoma Cells through ROS-Dependent Inhibition of the PI3K/Akt Signaling Pathway
por: Park, Cheol, et al.
Publicado: (2020)

Isorhamnetin Induces Cell Cycle Arrest and Apoptosis Via Reactive Oxygen Species-Mediated AMP-Activated Protein Kinase Signaling Pathway Activation in Human Bladder Cancer Cells
por: Park, Cheol, et al.
Publicado: (2019)

Phloroglucinol Attenuates DNA Damage and Apoptosis Induced by Oxidative Stress in Human Retinal Pigment Epithelium ARPE-19 Cells by Blocking the Production of Mitochondrial ROS
por: Park, Cheol, et al.
Publicado: (2022)

Honokiol ameliorates oxidative stress-induced DNA damage and apoptosis of c2c12 myoblasts by ROS generation and mitochondrial pathway
por: Park, Cheol, et al.
Publicado: (2019)

Schisandrae Fructus ethanol extract attenuates particulate matter 2.5-induced inflammatory and oxidative responses by blocking the activation of the ROS-dependent NF-κB signaling pathway
por: Lee, Hyesook, et al.
Publicado: (2021)

The immunostimulatory effect of indole-6-carboxaldehyde isolated from Sargassum thunbergii (Mertens) Kuntze in RAW 264.7 macrophages
por: Park, Cheol, et al.
Publicado: (2020)

Spermidine Attenuates Oxidative Stress-Induced Apoptosis via Blocking Ca(2+) Overload in Retinal Pigment Epithelial Cells Independently of ROS
por: Kim, Da Hye, et al.
Publicado: (2021)

The Protective Effect of Oral Application of Corni Fructus on the Disorders of the Cornea, Conjunctiva, Lacrimal Gland and Retina by Topical Particulate Matter 2.5
por: Lee, Hyesook, et al.
Publicado: (2021)

Citrus unshiu peel suppress the metastatic potential of murine melanoma B16F10 cells in vitro and in vivo
por: Choi, Eun Ok, et al.
Publicado: (2019)

Agaricus blazei Extract Induces Apoptosis through ROS-Dependent JNK Activation Involving the Mitochondrial Pathway and Suppression of Constitutive NF-κB in THP-1 Cells
por: Kim, Mun-Ock, et al.
Publicado: (2011)

Spermidine Attenuates High Glucose-Induced Oxidative Damage in Retinal Pigment Epithelial Cells by Inhibiting Production of ROS and NF-κB/NLRP3 Inflammasome Pathway
por: Bang, EunJin, et al.
Publicado: (2023)

Induction of G2/M Cell Cycle Arrest and Apoptosis by Genistein in Human Bladder Cancer T24 Cells through Inhibition of the ROS-Dependent PI3k/Akt Signal Transduction Pathway
por: Park, Cheol, et al.
Publicado: (2019)

Apoptosis Induction of Human Prostate Carcinoma DU145 Cells by Diallyl Disulfide via Modulation of JNK and PI3K/AKT Signaling Pathways
por: Shin, Dong Yeok, et al.
Publicado: (2012)

The Protective Effect of Topical Spermidine on Dry Eye Disease with Retinal Damage Induced by Diesel Particulate Matter2.5
por: Lee, Hyesook, et al.
Publicado: (2021)

The anti-cancer effect of betulinic acid in u937 human leukemia cells is mediated through ROS-dependent cell cycle arrest and apoptosis
por: Park, Cheol, et al.
Publicado: (2021)

Glutathione Induced Immune-Stimulatory Activity by Promoting M1-Like Macrophages Polarization via Potential ROS Scavenging Capacity
por: Kwon, Da Hye, et al.
Publicado: (2019)

Apoptosis Induction of Human Bladder Cancer Cells by Sanguinarine through Reactive Oxygen Species-Mediated Up-Regulation of Early Growth Response Gene-1
por: Han, Min Ho, et al.
Publicado: (2013)

A Novel Peptide Oligomer of Bacitracin Induces M1 Macrophage Polarization by Facilitating Ca(2+) Influx
por: Ji, Seon Yeong, et al.
Publicado: (2020)

β-Asarone Alleviates High-Glucose-Induced Oxidative Damage via Inhibition of ROS Generation and Inactivation of the NF-κB/NLRP3 Inflammasome Pathway in Human Retinal Pigment Epithelial Cells
por: Park, Cheol, et al.
Publicado: (2023)

Protection against Oxidative Stress-Induced Apoptosis by Fermented Sea Tangle (Laminaria japonica Aresch) in Osteoblastic MC3T3-E1 Cells through Activation of Nrf2 Signaling Pathway
por: Kim, So Young, et al.
Publicado: (2021)

Fermented Sea Tangle (Laminaria japonica Aresch) Suppresses RANKL-Induced Osteoclastogenesis by Scavenging ROS in RAW 264.7 Cells
por: Jeong, Jin-Woo, et al.
Publicado: (2019)

Neuroprotective Activity of Coptisine from Coptis chinensis (Franch)
por: Friedemann, Thomas, et al.
Publicado: (2015)

Antibacterial activity mechanism of coptisine against Pasteurella multocida
por: Zhang, Rui, et al.
Publicado: (2023)

Prostate Size Correlates with Fasting Blood Glucose in Non-Diabetic Benign Prostatic Hyperplasia Patients with Normal Testosterone Levels
por: Kim, Won Tae, et al.
Publicado: (2011)

Inhibitory Effect of Probenecid on Osteoclast Formation via JNK, ROS and COX-2
por: Cheng, Mi Hyun, et al.
Publicado: (2020)

Licochalcone B Induces ROS-Dependent Apoptosis in Oxaliplatin-Resistant Colorectal Cancer Cells via p38/JNK MAPK Signaling
por: Kwak, Ah-Won, et al.
Publicado: (2023)

Induction of Apoptosis by Fucoidan in Human Leukemia U937 Cells through Activation of p38 MAPK and Modulation of Bcl-2 Family
por: Park, Hyun Soo, et al.
Publicado: (2013)

Isorhamnetin alleviates lipopolysaccharide-induced inflammatory responses in BV2 microglia by inactivating NF-κB, blocking the TLR4 pathway and reducing ROS generation
por: Kim, Shin Young, et al.
Publicado: (2019)

Coptisine Inhibits Influenza Virus Replication by Upregulating p21
por: He, Ming-Feng, et al.
Publicado: (2023)

Fisetin Protects C2C12 Mouse Myoblasts from Oxidative Stress-Induced Cytotoxicity through Regulation of the Nrf2/HO-1 Signaling
por: Park, Cheol, et al.
Publicado: (2023)

Fucoidan Inhibits the Proliferation of Human Urinary Bladder Cancer T24 Cells by Blocking Cell Cycle Progression and Inducing Apoptosis
por: Park, Hye Young, et al.
Publicado: (2014)

Suppression of Lipopolysaccharide-Induced Inflammatory and Oxidative Response by 5-Aminolevulinic Acid in RAW 264.7 Macrophages and Zebrafish Larvae
por: Ji, Seon Yeong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ufeoh2bi6qbrgh37c4aft6iirb