The C3-H Bond Functionalization of Quinoxalin-2(1H)-Ones With Hypervalent Iodine(III) Reagents

The modification of quinoxalin-2(1H)-ones via direct C-H bond functionalization has begun to receive widespread attention, due to quinoxalin-2(1H)-one derivatives' various biological activities and pharmaceutical properties. This mini review concentrates on the accomplishments of arylation, tri...

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Autores principales: Tan, Yushi, Wang, Jiabo, Zhang, Hong-Yu, Zhang, Yuecheng, Zhao, Jiquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432307/
https://www.ncbi.nlm.nih.gov/pubmed/32850624
http://dx.doi.org/10.3389/fchem.2020.00582
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author Tan, Yushi
Wang, Jiabo
Zhang, Hong-Yu
Zhang, Yuecheng
Zhao, Jiquan
author_facet Tan, Yushi
Wang, Jiabo
Zhang, Hong-Yu
Zhang, Yuecheng
Zhao, Jiquan
author_sort Tan, Yushi
collection PubMed
description The modification of quinoxalin-2(1H)-ones via direct C-H bond functionalization has begun to receive widespread attention, due to quinoxalin-2(1H)-one derivatives' various biological activities and pharmaceutical properties. This mini review concentrates on the accomplishments of arylation, trifluoromethylation, alkylation, and alkoxylation of quinoxalin-2(1H)-ones with hypervalent iodine(III) reagents as reaction partners or oxidants. The reaction conditions and mechanisms are compared and discussed in detail.
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spelling pubmed-74323072020-08-25 The C3-H Bond Functionalization of Quinoxalin-2(1H)-Ones With Hypervalent Iodine(III) Reagents Tan, Yushi Wang, Jiabo Zhang, Hong-Yu Zhang, Yuecheng Zhao, Jiquan Front Chem Chemistry The modification of quinoxalin-2(1H)-ones via direct C-H bond functionalization has begun to receive widespread attention, due to quinoxalin-2(1H)-one derivatives' various biological activities and pharmaceutical properties. This mini review concentrates on the accomplishments of arylation, trifluoromethylation, alkylation, and alkoxylation of quinoxalin-2(1H)-ones with hypervalent iodine(III) reagents as reaction partners or oxidants. The reaction conditions and mechanisms are compared and discussed in detail. Frontiers Media S.A. 2020-08-03 /pmc/articles/PMC7432307/ /pubmed/32850624 http://dx.doi.org/10.3389/fchem.2020.00582 Text en Copyright © 2020 Tan, Wang, Zhang, Zhang and Zhao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Tan, Yushi
Wang, Jiabo
Zhang, Hong-Yu
Zhang, Yuecheng
Zhao, Jiquan
The C3-H Bond Functionalization of Quinoxalin-2(1H)-Ones With Hypervalent Iodine(III) Reagents
title The C3-H Bond Functionalization of Quinoxalin-2(1H)-Ones With Hypervalent Iodine(III) Reagents
title_full The C3-H Bond Functionalization of Quinoxalin-2(1H)-Ones With Hypervalent Iodine(III) Reagents
title_fullStr The C3-H Bond Functionalization of Quinoxalin-2(1H)-Ones With Hypervalent Iodine(III) Reagents
title_full_unstemmed The C3-H Bond Functionalization of Quinoxalin-2(1H)-Ones With Hypervalent Iodine(III) Reagents
title_short The C3-H Bond Functionalization of Quinoxalin-2(1H)-Ones With Hypervalent Iodine(III) Reagents
title_sort c3-h bond functionalization of quinoxalin-2(1h)-ones with hypervalent iodine(iii) reagents
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432307/
https://www.ncbi.nlm.nih.gov/pubmed/32850624
http://dx.doi.org/10.3389/fchem.2020.00582
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