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Basal Cell Carcinoma: A Comprehensive Review

Basal cell carcinoma (BCC) is the most common type of carcinoma worldwide. BCC development is the result of a complex interaction between environmental, phenotypic and genetic factors. However, despite the progress in the field, BCC biology and mechanisms of resistance against systemic treatments ha...

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Detalles Bibliográficos
Autores principales: Dika, Emi, Scarfì, Federica, Ferracin, Manuela, Broseghini, Elisabetta, Marcelli, Emanuela, Bortolani, Barbara, Campione, Elena, Riefolo, Mattia, Ricci, Costantino, Lambertini, Martina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432343/
https://www.ncbi.nlm.nih.gov/pubmed/32759706
http://dx.doi.org/10.3390/ijms21155572
Descripción
Sumario:Basal cell carcinoma (BCC) is the most common type of carcinoma worldwide. BCC development is the result of a complex interaction between environmental, phenotypic and genetic factors. However, despite the progress in the field, BCC biology and mechanisms of resistance against systemic treatments have been poorly investigated. The aim of the present review is to provide a revision of BCC histological and molecular features, including microRNA (miRNA) dysregulation, with a specific focus on the molecular basis of BCC systemic therapies. Papers from the last ten years regarding BCC genetic and phenotypic alterations, as well as the mechanism of resistance against hedgehog pathway inhibitors vismodegib and sonidegib were included. The involvement of miRNAs in BCC resistance to systemic therapies is emerging as a new field of knowledge.