(Phospho)proteomic Profiling of Microsatellite Unstable CRC Cells Reveals Alterations in Nuclear Signaling and Cholesterol Metabolism Caused by Frameshift Mutation of NMD Regulator UPF3A

DNA mismatch repair-deficient colorectal cancers (CRCs) accumulate numerous frameshift mutations at repetitive sequences recognized as microsatellite instability (MSI). When coding mononucleotide repeats (cMNRs) are affected, tumors accumulate frameshift mutations and premature termination codons (P...

Descripción completa

Detalles Bibliográficos
Autores principales: Michalak, Malwina, Katzenmaier, Eva-Maria, Roeckel, Nina, Woerner, Stefan M., Fuchs, Vera, Warnken, Uwe, Yuan, Yan P., Bork, Peer, Neu-Yilik, Gabriele, Kulozik, Andreas, von Knebel Doeberitz, Magnus, Kloor, Matthias, Kopitz, Jürgen, Gebert, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432364/
https://www.ncbi.nlm.nih.gov/pubmed/32718059
http://dx.doi.org/10.3390/ijms21155234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432364/
https://www.ncbi.nlm.nih.gov/pubmed/32718059
http://dx.doi.org/10.3390/ijms21155234

Ejemplares similares