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(Phospho)proteomic Profiling of Microsatellite Unstable CRC Cells Reveals Alterations in Nuclear Signaling and Cholesterol Metabolism Caused by Frameshift Mutation of NMD Regulator UPF3A
DNA mismatch repair-deficient colorectal cancers (CRCs) accumulate numerous frameshift mutations at repetitive sequences recognized as microsatellite instability (MSI). When coding mononucleotide repeats (cMNRs) are affected, tumors accumulate frameshift mutations and premature termination codons (P...
Autores principales: | Michalak, Malwina, Katzenmaier, Eva-Maria, Roeckel, Nina, Woerner, Stefan M., Fuchs, Vera, Warnken, Uwe, Yuan, Yan P., Bork, Peer, Neu-Yilik, Gabriele, Kulozik, Andreas, von Knebel Doeberitz, Magnus, Kloor, Matthias, Kopitz, Jürgen, Gebert, Johannes |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432364/ https://www.ncbi.nlm.nih.gov/pubmed/32718059 http://dx.doi.org/10.3390/ijms21155234 |
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