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Oxygenated Water Inhibits Adipogenesis and Attenuates Hepatic Steatosis in High-Fat Diet-Induced Obese Mice

The expansion of adipose tissue mass is the primary characteristic of the process of becoming obesity, which causes chronic adipose inflammation and is closely associated with type 2 diabetes mellitus (T2DM). Adipocyte hypertrophy restricts oxygen availability, leading to microenvironmental hypoxia...

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Autores principales: Cheng, Yuh-Jen, Liu, Chao-Chi, Chu, Fang-Yeh, Yang, Ching-Ping, Hsiao, Chiao-Wan, Chuang, Cheng-Wei, Shiau, Ming-Yuh, Lee, Hsueh-Te, Tsai, Jen-Ning, Chang, Yih-Hsin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432369/
https://www.ncbi.nlm.nih.gov/pubmed/32752112
http://dx.doi.org/10.3390/ijms21155493
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author Cheng, Yuh-Jen
Liu, Chao-Chi
Chu, Fang-Yeh
Yang, Ching-Ping
Hsiao, Chiao-Wan
Chuang, Cheng-Wei
Shiau, Ming-Yuh
Lee, Hsueh-Te
Tsai, Jen-Ning
Chang, Yih-Hsin
author_facet Cheng, Yuh-Jen
Liu, Chao-Chi
Chu, Fang-Yeh
Yang, Ching-Ping
Hsiao, Chiao-Wan
Chuang, Cheng-Wei
Shiau, Ming-Yuh
Lee, Hsueh-Te
Tsai, Jen-Ning
Chang, Yih-Hsin
author_sort Cheng, Yuh-Jen
collection PubMed
description The expansion of adipose tissue mass is the primary characteristic of the process of becoming obesity, which causes chronic adipose inflammation and is closely associated with type 2 diabetes mellitus (T2DM). Adipocyte hypertrophy restricts oxygen availability, leading to microenvironmental hypoxia and adipose dysfunction. This study aimed at investigating the effects of oxygenated water (OW) on adipocyte differentiation (adipogenesis) and the metabolic function of mature adipocytes. The effects of OW on adipogenesis and the metabolic function of mature adipocytes were examined. Meanwhile, the in vivo metabolic effects of long-term OW consumption on diet-induced obesity (DIO) mice were investigated. OW inhibited adipogenesis and lipid accumulation through down-regulating critical adipogenic transcription factors and lipogenic enzymes. While body weight, blood and adipose parameters were not significantly improved by long-term OW consumption, transient circulatory triglyceride-lowering and glucose tolerance-improving effects were identified. Notably, hepatic lipid contents were significantly reduced, indicating that the DIO-induced hepatic steatosis was attenuated, despite no improvements in fibrosis and lipid contents in adipose tissue being observed in the OW-drinking DIO mice. The study provides evidence regarding OW’s effects on adipogenesis and mature adipocytes, and the corresponding molecular mechanisms. OW exhibits transient triglyceride-lowering and glucose tolerance-improving activity as well as hepatic steatosis-attenuating functions.
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spelling pubmed-74323692020-08-24 Oxygenated Water Inhibits Adipogenesis and Attenuates Hepatic Steatosis in High-Fat Diet-Induced Obese Mice Cheng, Yuh-Jen Liu, Chao-Chi Chu, Fang-Yeh Yang, Ching-Ping Hsiao, Chiao-Wan Chuang, Cheng-Wei Shiau, Ming-Yuh Lee, Hsueh-Te Tsai, Jen-Ning Chang, Yih-Hsin Int J Mol Sci Article The expansion of adipose tissue mass is the primary characteristic of the process of becoming obesity, which causes chronic adipose inflammation and is closely associated with type 2 diabetes mellitus (T2DM). Adipocyte hypertrophy restricts oxygen availability, leading to microenvironmental hypoxia and adipose dysfunction. This study aimed at investigating the effects of oxygenated water (OW) on adipocyte differentiation (adipogenesis) and the metabolic function of mature adipocytes. The effects of OW on adipogenesis and the metabolic function of mature adipocytes were examined. Meanwhile, the in vivo metabolic effects of long-term OW consumption on diet-induced obesity (DIO) mice were investigated. OW inhibited adipogenesis and lipid accumulation through down-regulating critical adipogenic transcription factors and lipogenic enzymes. While body weight, blood and adipose parameters were not significantly improved by long-term OW consumption, transient circulatory triglyceride-lowering and glucose tolerance-improving effects were identified. Notably, hepatic lipid contents were significantly reduced, indicating that the DIO-induced hepatic steatosis was attenuated, despite no improvements in fibrosis and lipid contents in adipose tissue being observed in the OW-drinking DIO mice. The study provides evidence regarding OW’s effects on adipogenesis and mature adipocytes, and the corresponding molecular mechanisms. OW exhibits transient triglyceride-lowering and glucose tolerance-improving activity as well as hepatic steatosis-attenuating functions. MDPI 2020-07-31 /pmc/articles/PMC7432369/ /pubmed/32752112 http://dx.doi.org/10.3390/ijms21155493 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cheng, Yuh-Jen
Liu, Chao-Chi
Chu, Fang-Yeh
Yang, Ching-Ping
Hsiao, Chiao-Wan
Chuang, Cheng-Wei
Shiau, Ming-Yuh
Lee, Hsueh-Te
Tsai, Jen-Ning
Chang, Yih-Hsin
Oxygenated Water Inhibits Adipogenesis and Attenuates Hepatic Steatosis in High-Fat Diet-Induced Obese Mice
title Oxygenated Water Inhibits Adipogenesis and Attenuates Hepatic Steatosis in High-Fat Diet-Induced Obese Mice
title_full Oxygenated Water Inhibits Adipogenesis and Attenuates Hepatic Steatosis in High-Fat Diet-Induced Obese Mice
title_fullStr Oxygenated Water Inhibits Adipogenesis and Attenuates Hepatic Steatosis in High-Fat Diet-Induced Obese Mice
title_full_unstemmed Oxygenated Water Inhibits Adipogenesis and Attenuates Hepatic Steatosis in High-Fat Diet-Induced Obese Mice
title_short Oxygenated Water Inhibits Adipogenesis and Attenuates Hepatic Steatosis in High-Fat Diet-Induced Obese Mice
title_sort oxygenated water inhibits adipogenesis and attenuates hepatic steatosis in high-fat diet-induced obese mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432369/
https://www.ncbi.nlm.nih.gov/pubmed/32752112
http://dx.doi.org/10.3390/ijms21155493
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