RhoA/ROCK Pathway Activation is Regulated by AT1 Receptor and Participates in Smooth Muscle Migration and Dedifferentiation via Promoting Actin Cytoskeleton Polymerization

Background: In this study, we investigated the mechanism of Rho GTPases signaling on Ang II-mediated cell migration and dedifferentiation in human aortic vascular smooth muscle cells (HA-VSMCs) and an Ang II-infusion mouse model. Methods: Cells were pretreated with different inhibitors or Ang II. Ce...

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Detalles Bibliográficos
Autores principales: Qi, Yan, Liang, Xiuying, Dai, Fan, Guan, Haijing, Sun, Jingwen, Yao, Wenjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432407/
https://www.ncbi.nlm.nih.gov/pubmed/32751352
http://dx.doi.org/10.3390/ijms21155398

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