A Small Molecule, 4-Phenylbutyric Acid, Suppresses HCV Replication via Epigenetically Induced Hepatic Hepcidin

Hepatic hepcidin is a well-known major iron regulator and has been reported to be closely related to hepatitis C virus (HCV) replication. However, pharmacological targeting of the hepcidin in HCV replication has not been reported. A short-chain fatty acid, 4-Phenyl butyrate (4-PBA), is an acid chemi...

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Autores principales: Kim, Kiyoon, Lee, Young-seok, Jeong, Suyun, Kim, Daehong, Chon, Suk, Pak, Youngmi Kim, Kim, Sungsoo, Ha, Joohun, Kang, Insug, Choe, Wonchae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432483/
https://www.ncbi.nlm.nih.gov/pubmed/32752233
http://dx.doi.org/10.3390/ijms21155516

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