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Immunoglobulins with Non-Canonical Functions in Inflammatory and Autoimmune Disease States
Immunoglobulins are known to combine various effector mechanisms of the adaptive and the innate immune system. Classical immunoglobulin functions are associated with antigen recognition and the initiation of innate immune responses. However, in addition to classical functions, antibodies exhibit a v...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432551/ https://www.ncbi.nlm.nih.gov/pubmed/32751323 http://dx.doi.org/10.3390/ijms21155392 |
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author | Ermakov, Evgeny A. Nevinsky, Georgy A. Buneva, Valentina N. |
author_facet | Ermakov, Evgeny A. Nevinsky, Georgy A. Buneva, Valentina N. |
author_sort | Ermakov, Evgeny A. |
collection | PubMed |
description | Immunoglobulins are known to combine various effector mechanisms of the adaptive and the innate immune system. Classical immunoglobulin functions are associated with antigen recognition and the initiation of innate immune responses. However, in addition to classical functions, antibodies exhibit a variety of non-canonical functions related to the destruction of various pathogens due to catalytic activity and cofactor effects, the action of antibodies as agonists/antagonists of various receptors, the control of bacterial diversity of the intestine, etc. Canonical and non-canonical functions reflect the extreme human antibody repertoire and the variety of antibody types generated in the organism: antigen-specific, natural, polyreactive, broadly neutralizing, homophilic, bispecific and catalytic. The therapeutic effects of intravenous immunoglobulins (IVIg) are associated with both the canonical and non-canonical functions of antibodies. In this review, catalytic antibodies will be considered in more detail, since their formation is associated with inflammatory and autoimmune diseases. We will systematically summarize the diversity of catalytic antibodies in normal and pathological conditions. Translational perspectives of knowledge about natural antibodies for IVIg therapy will be also discussed. |
format | Online Article Text |
id | pubmed-7432551 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74325512020-08-24 Immunoglobulins with Non-Canonical Functions in Inflammatory and Autoimmune Disease States Ermakov, Evgeny A. Nevinsky, Georgy A. Buneva, Valentina N. Int J Mol Sci Review Immunoglobulins are known to combine various effector mechanisms of the adaptive and the innate immune system. Classical immunoglobulin functions are associated with antigen recognition and the initiation of innate immune responses. However, in addition to classical functions, antibodies exhibit a variety of non-canonical functions related to the destruction of various pathogens due to catalytic activity and cofactor effects, the action of antibodies as agonists/antagonists of various receptors, the control of bacterial diversity of the intestine, etc. Canonical and non-canonical functions reflect the extreme human antibody repertoire and the variety of antibody types generated in the organism: antigen-specific, natural, polyreactive, broadly neutralizing, homophilic, bispecific and catalytic. The therapeutic effects of intravenous immunoglobulins (IVIg) are associated with both the canonical and non-canonical functions of antibodies. In this review, catalytic antibodies will be considered in more detail, since their formation is associated with inflammatory and autoimmune diseases. We will systematically summarize the diversity of catalytic antibodies in normal and pathological conditions. Translational perspectives of knowledge about natural antibodies for IVIg therapy will be also discussed. MDPI 2020-07-29 /pmc/articles/PMC7432551/ /pubmed/32751323 http://dx.doi.org/10.3390/ijms21155392 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ermakov, Evgeny A. Nevinsky, Georgy A. Buneva, Valentina N. Immunoglobulins with Non-Canonical Functions in Inflammatory and Autoimmune Disease States |
title | Immunoglobulins with Non-Canonical Functions in Inflammatory and Autoimmune Disease States |
title_full | Immunoglobulins with Non-Canonical Functions in Inflammatory and Autoimmune Disease States |
title_fullStr | Immunoglobulins with Non-Canonical Functions in Inflammatory and Autoimmune Disease States |
title_full_unstemmed | Immunoglobulins with Non-Canonical Functions in Inflammatory and Autoimmune Disease States |
title_short | Immunoglobulins with Non-Canonical Functions in Inflammatory and Autoimmune Disease States |
title_sort | immunoglobulins with non-canonical functions in inflammatory and autoimmune disease states |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432551/ https://www.ncbi.nlm.nih.gov/pubmed/32751323 http://dx.doi.org/10.3390/ijms21155392 |
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