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The Role of the RNA-Binding Protein Family MEX-3 in Tumorigenesis
The muscle excess 3 (MEX-3) protein was first identified in Caenorhabditis elegans (C. elegans), and its respective homologues were also observed in vertebrates, including humans. It is a RNA-binding protein (RBP) with an additional ubiquitin E3 ligase function, which further acts as a post-transcri...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432607/ https://www.ncbi.nlm.nih.gov/pubmed/32717840 http://dx.doi.org/10.3390/ijms21155209 |
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author | Jasinski-Bergner, Simon Steven, André Seliger, Barbara |
author_facet | Jasinski-Bergner, Simon Steven, André Seliger, Barbara |
author_sort | Jasinski-Bergner, Simon |
collection | PubMed |
description | The muscle excess 3 (MEX-3) protein was first identified in Caenorhabditis elegans (C. elegans), and its respective homologues were also observed in vertebrates, including humans. It is a RNA-binding protein (RBP) with an additional ubiquitin E3 ligase function, which further acts as a post-transcriptional repressor through unknown mechanisms. In humans, MEX-3 proteins post-transcriptionally regulate a number of biological processes, including tumor immunological relevant ones. These have been shown to be involved in various diseases, including tumor diseases of distinct origins. This review provides information on the expression and function of the human MEX-3 family in healthy tissues, as well after malignant transformation. Indeed, the MEX-3 expression was shown to be deregulated in several cancers and to affect tumor biological functions, including apoptosis regulation, antigen processing, and presentation, thereby, contributing to the immune evasion of tumor cells. Furthermore, current research suggests MEX-3 proteins as putative markers for prognosis and as novel targets for the anti-cancer treatment. |
format | Online Article Text |
id | pubmed-7432607 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74326072020-08-27 The Role of the RNA-Binding Protein Family MEX-3 in Tumorigenesis Jasinski-Bergner, Simon Steven, André Seliger, Barbara Int J Mol Sci Review The muscle excess 3 (MEX-3) protein was first identified in Caenorhabditis elegans (C. elegans), and its respective homologues were also observed in vertebrates, including humans. It is a RNA-binding protein (RBP) with an additional ubiquitin E3 ligase function, which further acts as a post-transcriptional repressor through unknown mechanisms. In humans, MEX-3 proteins post-transcriptionally regulate a number of biological processes, including tumor immunological relevant ones. These have been shown to be involved in various diseases, including tumor diseases of distinct origins. This review provides information on the expression and function of the human MEX-3 family in healthy tissues, as well after malignant transformation. Indeed, the MEX-3 expression was shown to be deregulated in several cancers and to affect tumor biological functions, including apoptosis regulation, antigen processing, and presentation, thereby, contributing to the immune evasion of tumor cells. Furthermore, current research suggests MEX-3 proteins as putative markers for prognosis and as novel targets for the anti-cancer treatment. MDPI 2020-07-23 /pmc/articles/PMC7432607/ /pubmed/32717840 http://dx.doi.org/10.3390/ijms21155209 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jasinski-Bergner, Simon Steven, André Seliger, Barbara The Role of the RNA-Binding Protein Family MEX-3 in Tumorigenesis |
title | The Role of the RNA-Binding Protein Family MEX-3 in Tumorigenesis |
title_full | The Role of the RNA-Binding Protein Family MEX-3 in Tumorigenesis |
title_fullStr | The Role of the RNA-Binding Protein Family MEX-3 in Tumorigenesis |
title_full_unstemmed | The Role of the RNA-Binding Protein Family MEX-3 in Tumorigenesis |
title_short | The Role of the RNA-Binding Protein Family MEX-3 in Tumorigenesis |
title_sort | role of the rna-binding protein family mex-3 in tumorigenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432607/ https://www.ncbi.nlm.nih.gov/pubmed/32717840 http://dx.doi.org/10.3390/ijms21155209 |
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