The Orphan G-Protein Coupled Receptor 182 Is a Negative Regulator of Definitive Hematopoiesis through Leukotriene B4 Signaling

[Image: see text] The G protein-coupled receptor 182 (GPR182) is an orphan GPCR, the expression of which is enriched in embryonic endothelial cells (ECs). However, the physiological role and molecular mechanism of action of GPR182 are unknown. Here, we show that GPR182 negatively regulates definitiv...

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Detalles Bibliográficos
Autores principales: Kwon, Hyouk-Bum, Mackie, Duncan I., Bonnavion, Remy, Mercier, Alan Le, Helker, Christian S. M., Son, Taekwon, Guenter, Stefan, Serafin, D. Stephen, Kim, Kyu-Won, Offermanns, Stefan, Caron, Kathleen M., Stainier, Didier Y. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432686/
https://www.ncbi.nlm.nih.gov/pubmed/32832870
http://dx.doi.org/10.1021/acsptsci.0c00020

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