Drug Discovery Targeting the Disorder-To-Order Transition Regions through the Conformational Diversity Mimicking and Statistical Analysis

Intrinsically disordered proteins exist as highly dynamic conformational ensembles of diverse forms. However, the majority of virtual screening only focuses on proteins with defined structures. This means that computer-aided drug discovery is restricted. As a breakthrough, understanding the structur...

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Detalles Bibliográficos
Autores principales: Na, Insung, Choi, Sungwoo, Son, Seung Han, Uversky, Vladimir N., Kim, Chul Geun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432763/
https://www.ncbi.nlm.nih.gov/pubmed/32722024
http://dx.doi.org/10.3390/ijms21155248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432763/
https://www.ncbi.nlm.nih.gov/pubmed/32722024
http://dx.doi.org/10.3390/ijms21155248

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