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Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor

Genetic and biochemical evidence attributes neuronal loss in Parkinson’s disease (PD) and related brain diseases to dyshomeostasis of the 14 kDa protein α-synuclein (αS). There is no consensus on how αS exerts toxicity. Explanations range from disturbed vesicle biology to proteotoxicity caused by fi...

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Detalles Bibliográficos
Autores principales:	Terry-Kantor, Elizabeth, Tripathi, Arati, Imberdis, Thibaut, LaVoie, Zachary M., Ho, Gary P. H., Selkoe, Dennis, Fanning, Saranna, Ramalingam, Nagendran, Dettmer, Ulf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432784/ https://www.ncbi.nlm.nih.gov/pubmed/32707907 http://dx.doi.org/10.3390/ijms21155193

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