The Long-Lasting Protective Effect of HGF in Cardiomyoblasts Exposed to Doxorubicin Requires a Positive Feed-Forward Loop Mediated by Erk1,2-Timp1-Stat3

Previous studies showed that the hepatocyte growth factor (HGF)–Met receptor axis plays long-lasting cardioprotection against doxorubicin anti-cancer therapy. Here, we explored the mechanism(s) underlying the HGF protective effect. DNA damage was monitored by histone H2AX phosphorylation and apoptos...

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Detalles Bibliográficos
Autores principales: Gallo, Simona, Spilinga, Martina, Casanova, Elena, Bonzano, Alessandro, Boccaccio, Carla, Comoglio, Paolo Maria, Crepaldi, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432797/
https://www.ncbi.nlm.nih.gov/pubmed/32722178
http://dx.doi.org/10.3390/ijms21155258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432797/
https://www.ncbi.nlm.nih.gov/pubmed/32722178
http://dx.doi.org/10.3390/ijms21155258

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