Cargando…

The Long-Lasting Protective Effect of HGF in Cardiomyoblasts Exposed to Doxorubicin Requires a Positive Feed-Forward Loop Mediated by Erk1,2-Timp1-Stat3

Previous studies showed that the hepatocyte growth factor (HGF)–Met receptor axis plays long-lasting cardioprotection against doxorubicin anti-cancer therapy. Here, we explored the mechanism(s) underlying the HGF protective effect. DNA damage was monitored by histone H2AX phosphorylation and apoptos...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gallo, Simona, Spilinga, Martina, Casanova, Elena, Bonzano, Alessandro, Boccaccio, Carla, Comoglio, Paolo Maria, Crepaldi, Tiziana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432797/ https://www.ncbi.nlm.nih.gov/pubmed/32722178 http://dx.doi.org/10.3390/ijms21155258

Ejemplares similares

Activation of the MET receptor attenuates doxorubicin‐induced cardiotoxicity in vivo and in vitro
por: Gallo, Simona, et al.
Publicado: (2020)

ERK: A Key Player in the Pathophysiology of Cardiac Hypertrophy
por: Gallo, Simona, et al.
Publicado: (2019)

Agonist antibodies activating the Met receptor protect cardiomyoblasts from cobalt chloride-induced apoptosis and autophagy
por: Gallo, S, et al.
Publicado: (2014)

HGF and MET: From Brain Development to Neurological Disorders
por: Desole, Claudia, et al.
Publicado: (2021)

Engineering, Characterization, and Biological Evaluation of an Antibody Targeting the HGF Receptor
por: Desole, Claudia, et al.
Publicado: (2021)

HGF/Met Axis in Heart Function and Cardioprotection
por: Gallo, Simona, et al.
Publicado: (2014)

Molecular Engineering Strategies Tailoring the Apoptotic Response to a MET Therapeutic Antibody
por: Modica, Chiara, et al.
Publicado: (2020)

Capparis spinosa reduces Doxorubicin-induced cardio-toxicity in cardiomyoblast cells
por: Mousavi, Seyed Hadi, et al.
Publicado: (2016)

MET Oncogene Controls Invasive Growth by Coupling with NMDA Receptor
por: Gallo, Simona, et al.
Publicado: (2022)

Lipid Emulsion Inhibits the Late Apoptosis/Cardiotoxicity Induced by Doxorubicin in Rat Cardiomyoblasts
por: Subbarao, Raghavendra Baregundi, et al.
Publicado: (2018)

Protective Effect of Hibiscus Sabdariffa on Doxorubicin-induced Cytotoxicity in H9c2 Cardiomyoblast Cells
por: Hosseini, Azar, et al.
Publicado: (2017)

Recombinant TIMP-1-GPI inhibits growth of fibrosarcoma and enhances tumor sensitivity to doxorubicin
por: Bao, Q., et al.
Publicado: (2013)

HIF1α-dependent mitophagy facilitates cardiomyoblast differentiation
por: Zhao, Jin-Feng, et al.
Publicado: (2020)

Identification of novel circulating microRNAs in advanced heart failure by next‐generation sequencing
por: Galluzzo, Alessandro, et al.
Publicado: (2021)

Comparative studies of TIMP-1 immunohistochemistry, TIMP-1 FISH analysis and plasma TIMP-1 in glioblastoma patients
por: Aaberg-Jessen, Charlotte, et al.
Publicado: (2016)

Icariin Protects H9c2 Rat Cardiomyoblasts from Doxorubicin-Induced Cardiotoxicity: Role of Caveolin-1 Upregulation and Enhanced Autophagic Response
por: Scicchitano, Miriam, et al.
Publicado: (2021)

Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin
por: Shukla, Arti, et al.
Publicado: (2010)

The PSI Domain of the MET Oncogene Encodes a Functional Disulfide Isomerase Essential for the Maturation of the Receptor Precursor
por: Altintas, Dogus Murat, et al.
Publicado: (2022)

Protective effect of p-coumaric acid against doxorubicin induced toxicity in H9c2 cardiomyoblast cell lines
por: Chacko, Sunitha M., et al.
Publicado: (2015)

Afrostyrax lepidophyllus Mildbr. and Monodora myristica (Gaertn.) Dunal Extracts Decrease Doxorubicin Cytotoxicity on H9c2 Cardiomyoblasts
por: Moukette, Bruno M., et al.
Publicado: (2021)

Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors
por: Mira, Alessia, et al.
Publicado: (2017)

Simultaneous Inhibition of the HGF/MET and Erk1/2 Pathways Affect Uveal Melanoma Cell Growth and Migration
por: Chattopadhyay, Chandrani, et al.
Publicado: (2014)

MET/HGF Co-Targeting in Pancreatic Cancer: A Tool to Provide Insight into the Tumor/Stroma Crosstalk
por: Modica, Chiara, et al.
Publicado: (2018)

β4 integrin activates a Shp2–Src signaling pathway that sustains HGF-induced anchorage-independent growth
por: Bertotti, Andrea, et al.
Publicado: (2006)

Protective Effect of Two Alkaloids from Hippophae rhamnoides Linn. against Doxorubicin-Induced Toxicity in H9c2 Cardiomyoblasts
por: Zhou, Wenna, et al.
Publicado: (2021)

Ezrin Is an Effector of Hepatocyte Growth Factor–mediated Migration and Morphogenesis in Epithelial Cells
por: Crepaldi, Tiziana, et al.
Publicado: (1997)

Differential expression and localization of TIMP-1 and TIMP-4 in human gliomas
por: Groft, L L, et al.
Publicado: (2001)

BNC Protects H9c2 Cardiomyoblasts from H(2)O(2)-Induced Oxidative Injury through ERK1/2 Signaling Pathway
por: Zhang, Fangbo, et al.
Publicado: (2013)

Quercetin Reduces Inflammatory Responses in LPS-Stimulated Cardiomyoblasts
por: Angeloni, Cristina, et al.
Publicado: (2012)

New Insights About Doxorubicin-Induced Toxicity to Cardiomyoblast-Derived H9C2 Cells and Dexrazoxane Cytoprotective Effect: Contribution of In Vitro (1)H-NMR Metabonomics
por: Dallons, Matthieu, et al.
Publicado: (2020)

Variations in the expression of TIMP1, TIMP2 and TIMP3 in cutaneous melanoma with regression and their possible function as prognostic predictors
por: ZURAC, SABINA, et al.
Publicado: (2016)

TIMP1, TIMP2, and TIMP4 are increased in aqueous humor from primary open angle glaucoma patients
por: Briggs, Esther L. Ashworth, et al.
Publicado: (2015)

Rapamycin-Induced Apoptosis in HGF-Stimulated Lens Epithelial Cells by AKT/mTOR, ERK and JAK2/STAT3 Pathways
por: Tian, Fang, et al.
Publicado: (2014)

Imperatorin protects H9c2 cardiomyoblasts cells from hypoxia/reoxygenation-induced injury through activation of ERK signaling pathway
por: Liao, Bihong, et al.
Publicado: (2017)

Neferine ameliorates cardiomyoblast apoptosis induced by doxorubicin: possible role in modulating NADPH oxidase/ROS-mediated NFκB redox signaling cascade
por: Priya, Lohanathan Bharathi, et al.
Publicado: (2017)

Flavonoids from Hippophae rhamnoides Linn. Revert Doxorubicin-Induced Cardiotoxicity through Inhibition of Mitochondrial Dysfunction in H9c2 Cardiomyoblasts In Vitro
por: Zhou, Wenna, et al.
Publicado: (2023)

Tissue inhibitor of metalloproteinase 1 (TIMP-1) deficiency exacerbates carbon tetrachloride-induced liver injury and fibrosis in mice: involvement of hepatocyte STAT3 in TIMP-1 production
por: Wang, Hua, et al.
Publicado: (2011)

TIMP-1, TIMP-2 and MMP-9 as prognostic markers for clinical outcome in sepsis
por: Hoffmann, U, et al.
Publicado: (2003)

Asenapine modulates nitric oxide release and calcium movements in cardiomyoblasts
por: Grossini, Elena, et al.
Publicado: (2016)

Nkx2.5+ Cardiomyoblasts Contribute to Cardiomyogenesis in the Neonatal Heart
por: Serpooshan, Vahid, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_jh09ntjduu2kafm9bvclhlmc6v