2-Ketoglutarate-Generated In Vitro Enzymatic Biosystem Facilitates Fe(II)/2-Ketoglutarate-Dependent Dioxygenase-Mediated C–H Bond Oxidation for (2s,3r,4s)-4-Hydroxyisoleucine Synthesis

Fe(II)/2-ketoglutarate-dependent dioxygenase (Fe(II)/2-KG DO)-mediated hydroxylation is a critical type of C–H bond functionalization for synthesizing hydroxy amino acids used as pharmaceutical raw materials and precursors. However, DO activity requires 2-ketoglutarate (2-KG), lack of which reduces...

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Detalles Bibliográficos
Autores principales: Jing, Xiao-Ran, Liu, Huan, Nie, Yao, Xu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432852/
https://www.ncbi.nlm.nih.gov/pubmed/32731373
http://dx.doi.org/10.3390/ijms21155347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432852/
https://www.ncbi.nlm.nih.gov/pubmed/32731373
http://dx.doi.org/10.3390/ijms21155347

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