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HLA-B*44 and C*01 Prevalence Correlates with Covid19 Spreading across Italy

The spread of COVID-19 is showing huge, unexplained, differences between northern and southern Italy. We hypothesized that the regional prevalence of specific class I human leukocyte antigen (HLA) alleles, which shape the anti-viral immune response, might partly underlie these differences. Through a...

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Autores principales: Correale, Pierpaolo, Mutti, Luciano, Pentimalli, Francesca, Baglio, Giovanni, Saladino, Rita Emilena, Sileri, Pierpaolo, Giordano, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432860/
https://www.ncbi.nlm.nih.gov/pubmed/32717807
http://dx.doi.org/10.3390/ijms21155205
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author Correale, Pierpaolo
Mutti, Luciano
Pentimalli, Francesca
Baglio, Giovanni
Saladino, Rita Emilena
Sileri, Pierpaolo
Giordano, Antonio
author_facet Correale, Pierpaolo
Mutti, Luciano
Pentimalli, Francesca
Baglio, Giovanni
Saladino, Rita Emilena
Sileri, Pierpaolo
Giordano, Antonio
author_sort Correale, Pierpaolo
collection PubMed
description The spread of COVID-19 is showing huge, unexplained, differences between northern and southern Italy. We hypothesized that the regional prevalence of specific class I human leukocyte antigen (HLA) alleles, which shape the anti-viral immune response, might partly underlie these differences. Through an ecological approach, we analyzed whether a set of HLA alleles (A, B, C), known to be involved in the immune response against infections, correlates with COVID-19 incidence. COVID-19 data were provided by the National Civil Protection Department, whereas HLA allele prevalence was retrieved through the Italian Bone-Marrow Donors Registry. Among all the alleles, HLA-A*25, B*08, B*44, B*15:01, B*51, C*01, and C*03 showed a positive log-linear correlation with COVID-19 incidence rate fixed on 9 April 2020 in proximity of the national outbreak peak (Pearson’s coefficients between 0.50 and 0.70, p-value < 0.0001), whereas HLA-B*14, B*18, and B*49 showed an inverse log-linear correlation (Pearson’s coefficients between −0.47 and −0.59, p-value < 0.0001). When alleles were examined simultaneously using a multiple regression model to control for confounding factors, HLA-B*44 and C*01 were still positively and independently associated with COVID-19: a growth rate of 16% (95%CI: 0.1–35%) per 1% point increase in B*44 prevalence; and of 19% (95%CI: 1–41%) per 1% point increase in C*01 prevalence. Our epidemiologic analysis, despite the limits of the ecological approach, is strongly suggestive of a permissive role of HLA-C*01 and B*44 towards SARS-CoV-2 infection, which warrants further investigation in case-control studies. This study opens a new potential avenue for the identification of sub-populations at risk, which could provide Health Services with a tool to define more targeted clinical management strategies and priorities in vaccination campaigns.
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spelling pubmed-74328602020-08-28 HLA-B*44 and C*01 Prevalence Correlates with Covid19 Spreading across Italy Correale, Pierpaolo Mutti, Luciano Pentimalli, Francesca Baglio, Giovanni Saladino, Rita Emilena Sileri, Pierpaolo Giordano, Antonio Int J Mol Sci Communication The spread of COVID-19 is showing huge, unexplained, differences between northern and southern Italy. We hypothesized that the regional prevalence of specific class I human leukocyte antigen (HLA) alleles, which shape the anti-viral immune response, might partly underlie these differences. Through an ecological approach, we analyzed whether a set of HLA alleles (A, B, C), known to be involved in the immune response against infections, correlates with COVID-19 incidence. COVID-19 data were provided by the National Civil Protection Department, whereas HLA allele prevalence was retrieved through the Italian Bone-Marrow Donors Registry. Among all the alleles, HLA-A*25, B*08, B*44, B*15:01, B*51, C*01, and C*03 showed a positive log-linear correlation with COVID-19 incidence rate fixed on 9 April 2020 in proximity of the national outbreak peak (Pearson’s coefficients between 0.50 and 0.70, p-value < 0.0001), whereas HLA-B*14, B*18, and B*49 showed an inverse log-linear correlation (Pearson’s coefficients between −0.47 and −0.59, p-value < 0.0001). When alleles were examined simultaneously using a multiple regression model to control for confounding factors, HLA-B*44 and C*01 were still positively and independently associated with COVID-19: a growth rate of 16% (95%CI: 0.1–35%) per 1% point increase in B*44 prevalence; and of 19% (95%CI: 1–41%) per 1% point increase in C*01 prevalence. Our epidemiologic analysis, despite the limits of the ecological approach, is strongly suggestive of a permissive role of HLA-C*01 and B*44 towards SARS-CoV-2 infection, which warrants further investigation in case-control studies. This study opens a new potential avenue for the identification of sub-populations at risk, which could provide Health Services with a tool to define more targeted clinical management strategies and priorities in vaccination campaigns. MDPI 2020-07-23 /pmc/articles/PMC7432860/ /pubmed/32717807 http://dx.doi.org/10.3390/ijms21155205 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Correale, Pierpaolo
Mutti, Luciano
Pentimalli, Francesca
Baglio, Giovanni
Saladino, Rita Emilena
Sileri, Pierpaolo
Giordano, Antonio
HLA-B*44 and C*01 Prevalence Correlates with Covid19 Spreading across Italy
title HLA-B*44 and C*01 Prevalence Correlates with Covid19 Spreading across Italy
title_full HLA-B*44 and C*01 Prevalence Correlates with Covid19 Spreading across Italy
title_fullStr HLA-B*44 and C*01 Prevalence Correlates with Covid19 Spreading across Italy
title_full_unstemmed HLA-B*44 and C*01 Prevalence Correlates with Covid19 Spreading across Italy
title_short HLA-B*44 and C*01 Prevalence Correlates with Covid19 Spreading across Italy
title_sort hla-b*44 and c*01 prevalence correlates with covid19 spreading across italy
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432860/
https://www.ncbi.nlm.nih.gov/pubmed/32717807
http://dx.doi.org/10.3390/ijms21155205
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