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The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma

Treatment for osteosarcoma (OS) has been largely unchanged for several decades, with typical therapies being a mixture of chemotherapy and surgery. Although therapeutic targets and products against cancer are being continually developed, only a limited number have proved therapeutically active in OS...

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Detalles Bibliográficos
Autores principales: Smith, Hannah L., Beers, Stephen A., Gray, Juliet C., Kanczler, Janos M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432883/
https://www.ncbi.nlm.nih.gov/pubmed/32752092
http://dx.doi.org/10.3390/ijms21155499
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author Smith, Hannah L.
Beers, Stephen A.
Gray, Juliet C.
Kanczler, Janos M.
author_facet Smith, Hannah L.
Beers, Stephen A.
Gray, Juliet C.
Kanczler, Janos M.
author_sort Smith, Hannah L.
collection PubMed
description Treatment for osteosarcoma (OS) has been largely unchanged for several decades, with typical therapies being a mixture of chemotherapy and surgery. Although therapeutic targets and products against cancer are being continually developed, only a limited number have proved therapeutically active in OS. Thus, the understanding of the OS microenvironment and its interactions are becoming more important in developing new therapies. Three-dimensional (3D) models are important tools in increasing our understanding of complex mechanisms and interactions, such as in OS. In this review, in vivo animal models, in vitro 3D models and in ovo chorioallantoic membrane (CAM) models, are evaluated and discussed as to their contribution in understanding the progressive nature of OS, and cancer research. We aim to provide insight and prospective future directions into the potential translation of 3D models in OS.
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spelling pubmed-74328832020-08-28 The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma Smith, Hannah L. Beers, Stephen A. Gray, Juliet C. Kanczler, Janos M. Int J Mol Sci Review Treatment for osteosarcoma (OS) has been largely unchanged for several decades, with typical therapies being a mixture of chemotherapy and surgery. Although therapeutic targets and products against cancer are being continually developed, only a limited number have proved therapeutically active in OS. Thus, the understanding of the OS microenvironment and its interactions are becoming more important in developing new therapies. Three-dimensional (3D) models are important tools in increasing our understanding of complex mechanisms and interactions, such as in OS. In this review, in vivo animal models, in vitro 3D models and in ovo chorioallantoic membrane (CAM) models, are evaluated and discussed as to their contribution in understanding the progressive nature of OS, and cancer research. We aim to provide insight and prospective future directions into the potential translation of 3D models in OS. MDPI 2020-07-31 /pmc/articles/PMC7432883/ /pubmed/32752092 http://dx.doi.org/10.3390/ijms21155499 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Smith, Hannah L.
Beers, Stephen A.
Gray, Juliet C.
Kanczler, Janos M.
The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma
title The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma
title_full The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma
title_fullStr The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma
title_full_unstemmed The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma
title_short The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma
title_sort role of pre-clinical 3-dimensional models of osteosarcoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432883/
https://www.ncbi.nlm.nih.gov/pubmed/32752092
http://dx.doi.org/10.3390/ijms21155499
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