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The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma
Treatment for osteosarcoma (OS) has been largely unchanged for several decades, with typical therapies being a mixture of chemotherapy and surgery. Although therapeutic targets and products against cancer are being continually developed, only a limited number have proved therapeutically active in OS...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432883/ https://www.ncbi.nlm.nih.gov/pubmed/32752092 http://dx.doi.org/10.3390/ijms21155499 |
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author | Smith, Hannah L. Beers, Stephen A. Gray, Juliet C. Kanczler, Janos M. |
author_facet | Smith, Hannah L. Beers, Stephen A. Gray, Juliet C. Kanczler, Janos M. |
author_sort | Smith, Hannah L. |
collection | PubMed |
description | Treatment for osteosarcoma (OS) has been largely unchanged for several decades, with typical therapies being a mixture of chemotherapy and surgery. Although therapeutic targets and products against cancer are being continually developed, only a limited number have proved therapeutically active in OS. Thus, the understanding of the OS microenvironment and its interactions are becoming more important in developing new therapies. Three-dimensional (3D) models are important tools in increasing our understanding of complex mechanisms and interactions, such as in OS. In this review, in vivo animal models, in vitro 3D models and in ovo chorioallantoic membrane (CAM) models, are evaluated and discussed as to their contribution in understanding the progressive nature of OS, and cancer research. We aim to provide insight and prospective future directions into the potential translation of 3D models in OS. |
format | Online Article Text |
id | pubmed-7432883 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74328832020-08-28 The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma Smith, Hannah L. Beers, Stephen A. Gray, Juliet C. Kanczler, Janos M. Int J Mol Sci Review Treatment for osteosarcoma (OS) has been largely unchanged for several decades, with typical therapies being a mixture of chemotherapy and surgery. Although therapeutic targets and products against cancer are being continually developed, only a limited number have proved therapeutically active in OS. Thus, the understanding of the OS microenvironment and its interactions are becoming more important in developing new therapies. Three-dimensional (3D) models are important tools in increasing our understanding of complex mechanisms and interactions, such as in OS. In this review, in vivo animal models, in vitro 3D models and in ovo chorioallantoic membrane (CAM) models, are evaluated and discussed as to their contribution in understanding the progressive nature of OS, and cancer research. We aim to provide insight and prospective future directions into the potential translation of 3D models in OS. MDPI 2020-07-31 /pmc/articles/PMC7432883/ /pubmed/32752092 http://dx.doi.org/10.3390/ijms21155499 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Smith, Hannah L. Beers, Stephen A. Gray, Juliet C. Kanczler, Janos M. The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma |
title | The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma |
title_full | The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma |
title_fullStr | The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma |
title_full_unstemmed | The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma |
title_short | The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma |
title_sort | role of pre-clinical 3-dimensional models of osteosarcoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432883/ https://www.ncbi.nlm.nih.gov/pubmed/32752092 http://dx.doi.org/10.3390/ijms21155499 |
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