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Review of the existing maximum residue levels for propineb according to Article 12 of Regulation (EC) No 396/2005

According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance propineb. Although this active substance is no longer authorised within the EU, due to insufficient information in or...

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Autores principales: Anastassiadou, Maria, Bernasconi, Giovanni, Brancato, Alba, Carrasco Cabrera, Luis, Ferreira, Lucien, Greco, Luna, Jarrah, Samira, Kazocina, Aija, Leuschner, Renata, Magrans, Jose Oriol, Miron, Ileana, Nave, Stefanie, Pedersen, Ragnor, Reich, Hermine, Rojas, Alejandro, Sacchi, Angela, Santos, Miguel, Theobald, Anne, Vagenende, Benedicte, Verani, Alessia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433000/
https://www.ncbi.nlm.nih.gov/pubmed/32831950
http://dx.doi.org/10.2903/j.efsa.2020.6233
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author Anastassiadou, Maria
Bernasconi, Giovanni
Brancato, Alba
Carrasco Cabrera, Luis
Ferreira, Lucien
Greco, Luna
Jarrah, Samira
Kazocina, Aija
Leuschner, Renata
Magrans, Jose Oriol
Miron, Ileana
Nave, Stefanie
Pedersen, Ragnor
Reich, Hermine
Rojas, Alejandro
Sacchi, Angela
Santos, Miguel
Theobald, Anne
Vagenende, Benedicte
Verani, Alessia
author_facet Anastassiadou, Maria
Bernasconi, Giovanni
Brancato, Alba
Carrasco Cabrera, Luis
Ferreira, Lucien
Greco, Luna
Jarrah, Samira
Kazocina, Aija
Leuschner, Renata
Magrans, Jose Oriol
Miron, Ileana
Nave, Stefanie
Pedersen, Ragnor
Reich, Hermine
Rojas, Alejandro
Sacchi, Angela
Santos, Miguel
Theobald, Anne
Vagenende, Benedicte
Verani, Alessia
collection PubMed
description According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance propineb. Although this active substance is no longer authorised within the EU, due to insufficient information in order to conclude on the consumer risk assessment for the active substance, the toxicity of the metabolite propane‐1,2‐diamine (PDA) the impact on non‐target organisms and the risk to honeybees, MRLs based on the use of propineb were established by the Codex Alimentarius Commission (codex maximum residue limits; CXLs) and are still in place. Additionally, propineb has potential endocrine‐disrupting properties related to the hazards of its major metabolite 4‐methylimidazolidine‐2‐thione (PTU). Lacking a full toxicological characterisation for the compound PDA, exposure data for metabolites propineb‐DIDT in plants and PDA in processed commodities and considering that propineb‐MRLs correlated to CXLs were based on EU uses that were withdrawn following the non‐renewal and are no longer in place, it was not possible for EFSA to perform an assessment of these MRLs and their incorporation in European legislation cannot be recommended. Nevertheless, available data allowed EFSA to propose a marker residue and a limit of quantification (LOQ) for enforcement against potential illegal uses.
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spelling pubmed-74330002020-08-20 Review of the existing maximum residue levels for propineb according to Article 12 of Regulation (EC) No 396/2005 Anastassiadou, Maria Bernasconi, Giovanni Brancato, Alba Carrasco Cabrera, Luis Ferreira, Lucien Greco, Luna Jarrah, Samira Kazocina, Aija Leuschner, Renata Magrans, Jose Oriol Miron, Ileana Nave, Stefanie Pedersen, Ragnor Reich, Hermine Rojas, Alejandro Sacchi, Angela Santos, Miguel Theobald, Anne Vagenende, Benedicte Verani, Alessia EFSA J Reasoned Opinion According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance propineb. Although this active substance is no longer authorised within the EU, due to insufficient information in order to conclude on the consumer risk assessment for the active substance, the toxicity of the metabolite propane‐1,2‐diamine (PDA) the impact on non‐target organisms and the risk to honeybees, MRLs based on the use of propineb were established by the Codex Alimentarius Commission (codex maximum residue limits; CXLs) and are still in place. Additionally, propineb has potential endocrine‐disrupting properties related to the hazards of its major metabolite 4‐methylimidazolidine‐2‐thione (PTU). Lacking a full toxicological characterisation for the compound PDA, exposure data for metabolites propineb‐DIDT in plants and PDA in processed commodities and considering that propineb‐MRLs correlated to CXLs were based on EU uses that were withdrawn following the non‐renewal and are no longer in place, it was not possible for EFSA to perform an assessment of these MRLs and their incorporation in European legislation cannot be recommended. Nevertheless, available data allowed EFSA to propose a marker residue and a limit of quantification (LOQ) for enforcement against potential illegal uses. John Wiley and Sons Inc. 2020-08-18 /pmc/articles/PMC7433000/ /pubmed/32831950 http://dx.doi.org/10.2903/j.efsa.2020.6233 Text en © 2020 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Reasoned Opinion
Anastassiadou, Maria
Bernasconi, Giovanni
Brancato, Alba
Carrasco Cabrera, Luis
Ferreira, Lucien
Greco, Luna
Jarrah, Samira
Kazocina, Aija
Leuschner, Renata
Magrans, Jose Oriol
Miron, Ileana
Nave, Stefanie
Pedersen, Ragnor
Reich, Hermine
Rojas, Alejandro
Sacchi, Angela
Santos, Miguel
Theobald, Anne
Vagenende, Benedicte
Verani, Alessia
Review of the existing maximum residue levels for propineb according to Article 12 of Regulation (EC) No 396/2005
title Review of the existing maximum residue levels for propineb according to Article 12 of Regulation (EC) No 396/2005
title_full Review of the existing maximum residue levels for propineb according to Article 12 of Regulation (EC) No 396/2005
title_fullStr Review of the existing maximum residue levels for propineb according to Article 12 of Regulation (EC) No 396/2005
title_full_unstemmed Review of the existing maximum residue levels for propineb according to Article 12 of Regulation (EC) No 396/2005
title_short Review of the existing maximum residue levels for propineb according to Article 12 of Regulation (EC) No 396/2005
title_sort review of the existing maximum residue levels for propineb according to article 12 of regulation (ec) no 396/2005
topic Reasoned Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433000/
https://www.ncbi.nlm.nih.gov/pubmed/32831950
http://dx.doi.org/10.2903/j.efsa.2020.6233
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