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Gray whale transcriptome reveals longevity adaptations associated with DNA repair and ubiquitination

One important question in aging research is how differences in genomics and transcriptomics determine the maximum lifespan in various species. Despite recent progress, much is still unclear on the topic, partly due to the lack of samples in nonmodel organisms and due to challenges in direct comparis...

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Autores principales: Toren, Dmitri, Kulaga, Anton, Jethva, Mineshbhai, Rubin, Eitan, Snezhkina, Anastasia V., Kudryavtseva, Anna V., Nowicki, Dmitry, Tacutu, Robi, Moskalev, Alexey A., Fraifeld, Vadim E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433004/
https://www.ncbi.nlm.nih.gov/pubmed/32515539
http://dx.doi.org/10.1111/acel.13158
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author Toren, Dmitri
Kulaga, Anton
Jethva, Mineshbhai
Rubin, Eitan
Snezhkina, Anastasia V.
Kudryavtseva, Anna V.
Nowicki, Dmitry
Tacutu, Robi
Moskalev, Alexey A.
Fraifeld, Vadim E.
author_facet Toren, Dmitri
Kulaga, Anton
Jethva, Mineshbhai
Rubin, Eitan
Snezhkina, Anastasia V.
Kudryavtseva, Anna V.
Nowicki, Dmitry
Tacutu, Robi
Moskalev, Alexey A.
Fraifeld, Vadim E.
author_sort Toren, Dmitri
collection PubMed
description One important question in aging research is how differences in genomics and transcriptomics determine the maximum lifespan in various species. Despite recent progress, much is still unclear on the topic, partly due to the lack of samples in nonmodel organisms and due to challenges in direct comparisons of transcriptomes from different species. The novel ranking‐based method that we employ here is used to analyze gene expression in the gray whale and compare its de novo assembled transcriptome with that of other long‐ and short‐lived mammals. Gray whales are among the top 1% longest‐lived mammals. Despite the extreme environment, or maybe due to a remarkable adaptation to its habitat (intermittent hypoxia, Arctic water, and high pressure), gray whales reach at least the age of 77 years. In this work, we show that long‐lived mammals share common gene expression patterns between themselves, including high expression of DNA maintenance and repair, ubiquitination, apoptosis, and immune responses. Additionally, the level of expression for gray whale orthologs of pro‐ and anti‐longevity genes found in model organisms is in support of their alleged role and direction in lifespan determination. Remarkably, among highly expressed pro‐longevity genes many are stress‐related, reflecting an adaptation to extreme environmental conditions. The conducted analysis suggests that the gray whale potentially possesses high resistance to cancer and stress, at least in part ensuring its longevity. This new transcriptome assembly also provides important resources to support the efforts of maintaining the endangered population of gray whales.
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spelling pubmed-74330042020-08-20 Gray whale transcriptome reveals longevity adaptations associated with DNA repair and ubiquitination Toren, Dmitri Kulaga, Anton Jethva, Mineshbhai Rubin, Eitan Snezhkina, Anastasia V. Kudryavtseva, Anna V. Nowicki, Dmitry Tacutu, Robi Moskalev, Alexey A. Fraifeld, Vadim E. Aging Cell Original Papers One important question in aging research is how differences in genomics and transcriptomics determine the maximum lifespan in various species. Despite recent progress, much is still unclear on the topic, partly due to the lack of samples in nonmodel organisms and due to challenges in direct comparisons of transcriptomes from different species. The novel ranking‐based method that we employ here is used to analyze gene expression in the gray whale and compare its de novo assembled transcriptome with that of other long‐ and short‐lived mammals. Gray whales are among the top 1% longest‐lived mammals. Despite the extreme environment, or maybe due to a remarkable adaptation to its habitat (intermittent hypoxia, Arctic water, and high pressure), gray whales reach at least the age of 77 years. In this work, we show that long‐lived mammals share common gene expression patterns between themselves, including high expression of DNA maintenance and repair, ubiquitination, apoptosis, and immune responses. Additionally, the level of expression for gray whale orthologs of pro‐ and anti‐longevity genes found in model organisms is in support of their alleged role and direction in lifespan determination. Remarkably, among highly expressed pro‐longevity genes many are stress‐related, reflecting an adaptation to extreme environmental conditions. The conducted analysis suggests that the gray whale potentially possesses high resistance to cancer and stress, at least in part ensuring its longevity. This new transcriptome assembly also provides important resources to support the efforts of maintaining the endangered population of gray whales. John Wiley and Sons Inc. 2020-06-09 2020-07 /pmc/articles/PMC7433004/ /pubmed/32515539 http://dx.doi.org/10.1111/acel.13158 Text en © 2020 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Papers
Toren, Dmitri
Kulaga, Anton
Jethva, Mineshbhai
Rubin, Eitan
Snezhkina, Anastasia V.
Kudryavtseva, Anna V.
Nowicki, Dmitry
Tacutu, Robi
Moskalev, Alexey A.
Fraifeld, Vadim E.
Gray whale transcriptome reveals longevity adaptations associated with DNA repair and ubiquitination
title Gray whale transcriptome reveals longevity adaptations associated with DNA repair and ubiquitination
title_full Gray whale transcriptome reveals longevity adaptations associated with DNA repair and ubiquitination
title_fullStr Gray whale transcriptome reveals longevity adaptations associated with DNA repair and ubiquitination
title_full_unstemmed Gray whale transcriptome reveals longevity adaptations associated with DNA repair and ubiquitination
title_short Gray whale transcriptome reveals longevity adaptations associated with DNA repair and ubiquitination
title_sort gray whale transcriptome reveals longevity adaptations associated with dna repair and ubiquitination
topic Original Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433004/
https://www.ncbi.nlm.nih.gov/pubmed/32515539
http://dx.doi.org/10.1111/acel.13158
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