Comprehensive analysis of the mechanism and treatment significance of Mucins in lung cancer

Aberrant expression of mucin proteins has played a complex and essential role in cancer development and metastasis. Members of the mucin family have been intimately implicated in lung cancer progression, metastasis, survival and chemo-resistance. During the progression of lung cancer, mucin proteins...

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Autores principales: Ning, Yue, Zheng, Hongmei, Zhan, Yuting, Liu, Sile, yang, Yang, Zang, Hongjing, Luo, Jiadi, Wen, Qiuyuan, Fan, Songqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433199/
https://www.ncbi.nlm.nih.gov/pubmed/32807223
http://dx.doi.org/10.1186/s13046-020-01662-3
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author Ning, Yue
Zheng, Hongmei
Zhan, Yuting
Liu, Sile
yang, Yang
Zang, Hongjing
Luo, Jiadi
Wen, Qiuyuan
Fan, Songqing
author_facet Ning, Yue
Zheng, Hongmei
Zhan, Yuting
Liu, Sile
yang, Yang
Zang, Hongjing
Luo, Jiadi
Wen, Qiuyuan
Fan, Songqing
author_sort Ning, Yue
collection PubMed
description Aberrant expression of mucin proteins has played a complex and essential role in cancer development and metastasis. Members of the mucin family have been intimately implicated in lung cancer progression, metastasis, survival and chemo-resistance. During the progression of lung cancer, mucin proteins have involved all of the procession of lung cancer, which is interacted with many receptor tyrosine kinases signal pathways and mediated cell signals for tumor cell growth and survival. Mucins thus have been considerable as the indicator of negative prognosis and desirable therapeutic targets of lung cancers. In this review, we comprehensively analyzed the role of each member of the mucin family in lung cancer by combining open-accessed database analysis and assembling cutting-edge information about these molecules.
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spelling pubmed-74331992020-08-19 Comprehensive analysis of the mechanism and treatment significance of Mucins in lung cancer Ning, Yue Zheng, Hongmei Zhan, Yuting Liu, Sile yang, Yang Zang, Hongjing Luo, Jiadi Wen, Qiuyuan Fan, Songqing J Exp Clin Cancer Res Review Aberrant expression of mucin proteins has played a complex and essential role in cancer development and metastasis. Members of the mucin family have been intimately implicated in lung cancer progression, metastasis, survival and chemo-resistance. During the progression of lung cancer, mucin proteins have involved all of the procession of lung cancer, which is interacted with many receptor tyrosine kinases signal pathways and mediated cell signals for tumor cell growth and survival. Mucins thus have been considerable as the indicator of negative prognosis and desirable therapeutic targets of lung cancers. In this review, we comprehensively analyzed the role of each member of the mucin family in lung cancer by combining open-accessed database analysis and assembling cutting-edge information about these molecules. BioMed Central 2020-08-17 /pmc/articles/PMC7433199/ /pubmed/32807223 http://dx.doi.org/10.1186/s13046-020-01662-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Ning, Yue
Zheng, Hongmei
Zhan, Yuting
Liu, Sile
yang, Yang
Zang, Hongjing
Luo, Jiadi
Wen, Qiuyuan
Fan, Songqing
Comprehensive analysis of the mechanism and treatment significance of Mucins in lung cancer
title Comprehensive analysis of the mechanism and treatment significance of Mucins in lung cancer
title_full Comprehensive analysis of the mechanism and treatment significance of Mucins in lung cancer
title_fullStr Comprehensive analysis of the mechanism and treatment significance of Mucins in lung cancer
title_full_unstemmed Comprehensive analysis of the mechanism and treatment significance of Mucins in lung cancer
title_short Comprehensive analysis of the mechanism and treatment significance of Mucins in lung cancer
title_sort comprehensive analysis of the mechanism and treatment significance of mucins in lung cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433199/
https://www.ncbi.nlm.nih.gov/pubmed/32807223
http://dx.doi.org/10.1186/s13046-020-01662-3
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