Neural compensation in presymptomatic hAPP mouse models of Alzheimer's disease

Largely inspired from clinical concepts like brain reserve, cognitive reserve, and neural compensation, here we review data showing how neural circuits reorganize in presymptomatic and early symptomatic hAPP mice to maintain memory intact. By informing on molecular alterations and compensatory adapt...

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Detalles Bibliográficos
Autor principal: Ammassari-Teule, Martine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433654/
https://www.ncbi.nlm.nih.gov/pubmed/32817305
http://dx.doi.org/10.1101/lm.050401.119
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author Ammassari-Teule, Martine
author_facet Ammassari-Teule, Martine
author_sort Ammassari-Teule, Martine
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description Largely inspired from clinical concepts like brain reserve, cognitive reserve, and neural compensation, here we review data showing how neural circuits reorganize in presymptomatic and early symptomatic hAPP mice to maintain memory intact. By informing on molecular alterations and compensatory adaptations which take place in the brain before mice show cognitive impairments, these data can help to identify ultra-early disease markers that could be targeted in a therapeutic perspective aimed at preventing rather than treating cognitive deterioration.
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spelling pubmed-74336542021-09-01 Neural compensation in presymptomatic hAPP mouse models of Alzheimer's disease Ammassari-Teule, Martine Learn Mem Review Largely inspired from clinical concepts like brain reserve, cognitive reserve, and neural compensation, here we review data showing how neural circuits reorganize in presymptomatic and early symptomatic hAPP mice to maintain memory intact. By informing on molecular alterations and compensatory adaptations which take place in the brain before mice show cognitive impairments, these data can help to identify ultra-early disease markers that could be targeted in a therapeutic perspective aimed at preventing rather than treating cognitive deterioration. Cold Spring Harbor Laboratory Press 2020-09 /pmc/articles/PMC7433654/ /pubmed/32817305 http://dx.doi.org/10.1101/lm.050401.119 Text en © 2020 Ammassari-Teule; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Review
Ammassari-Teule, Martine
Neural compensation in presymptomatic hAPP mouse models of Alzheimer's disease
title Neural compensation in presymptomatic hAPP mouse models of Alzheimer's disease
title_full Neural compensation in presymptomatic hAPP mouse models of Alzheimer's disease
title_fullStr Neural compensation in presymptomatic hAPP mouse models of Alzheimer's disease
title_full_unstemmed Neural compensation in presymptomatic hAPP mouse models of Alzheimer's disease
title_short Neural compensation in presymptomatic hAPP mouse models of Alzheimer's disease
title_sort neural compensation in presymptomatic happ mouse models of alzheimer's disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433654/
https://www.ncbi.nlm.nih.gov/pubmed/32817305
http://dx.doi.org/10.1101/lm.050401.119
work_keys_str_mv AT ammassariteulemartine neuralcompensationinpresymptomatichappmousemodelsofalzheimersdisease

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