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Significance of Extranodal Extension in Surgically Treated HPV-Positive Oropharyngeal Carcinomas
Squamous cell carcinomas of the head and neck are the subject of numerous current studies, especially in view of the increasing incidence of tumors induced by human papillomavirus (HPV) and the latest changes to the TNM classification of oropharyngeal squamous cell carcinoma (OPSCC). In addition to...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433688/ https://www.ncbi.nlm.nih.gov/pubmed/32850449 http://dx.doi.org/10.3389/fonc.2020.01394 |
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author | Beltz, Anna Zimmer, Stefanie Michaelides, Ioannis Evert, Katja Psychogios, Georgios Bohr, Christopher Künzel, Julian |
author_facet | Beltz, Anna Zimmer, Stefanie Michaelides, Ioannis Evert, Katja Psychogios, Georgios Bohr, Christopher Künzel, Julian |
author_sort | Beltz, Anna |
collection | PubMed |
description | Squamous cell carcinomas of the head and neck are the subject of numerous current studies, especially in view of the increasing incidence of tumors induced by human papillomavirus (HPV) and the latest changes to the TNM classification of oropharyngeal squamous cell carcinoma (OPSCC). In addition to HPV status, the presence of extranodal extension of lymph node metastases represents an important risk and prognostic factor, which has now been integrated into the staging algorithm of the eighth edition of TNM classification for HPV-negative OPSCC. In the past numerous studies had shown a lack of prognostic significance of extranodal extension in HPV-associated tumors. However, extranodal extension–as a possible risk factor even in HPV-positive OPSCC–remains an important subject of current studies, which are now particularly characterized by high numbers of cases. In this paper, diagnostic methods and the prognostic significance of extranodal extension in surgically treated HPV-positive OPSCC are presented and discussed based on relevant literature, and the results of current publications are summarized. Further development of diagnostic criteria and procedures as well as international standardization of clinical diagnostics of extranodal extension should be encouraged. Several studies demonstrate that extranodal extension results in worse survival outcomes even in HPV-positive tumors, in contrast to results of previous studies. Consequently, whether the prognostic significance of extranodal extension is not actually relevant to outcome and the staging algorithm of HPV-positive OPSCC should be questioned and further analyzed. |
format | Online Article Text |
id | pubmed-7433688 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74336882020-08-25 Significance of Extranodal Extension in Surgically Treated HPV-Positive Oropharyngeal Carcinomas Beltz, Anna Zimmer, Stefanie Michaelides, Ioannis Evert, Katja Psychogios, Georgios Bohr, Christopher Künzel, Julian Front Oncol Oncology Squamous cell carcinomas of the head and neck are the subject of numerous current studies, especially in view of the increasing incidence of tumors induced by human papillomavirus (HPV) and the latest changes to the TNM classification of oropharyngeal squamous cell carcinoma (OPSCC). In addition to HPV status, the presence of extranodal extension of lymph node metastases represents an important risk and prognostic factor, which has now been integrated into the staging algorithm of the eighth edition of TNM classification for HPV-negative OPSCC. In the past numerous studies had shown a lack of prognostic significance of extranodal extension in HPV-associated tumors. However, extranodal extension–as a possible risk factor even in HPV-positive OPSCC–remains an important subject of current studies, which are now particularly characterized by high numbers of cases. In this paper, diagnostic methods and the prognostic significance of extranodal extension in surgically treated HPV-positive OPSCC are presented and discussed based on relevant literature, and the results of current publications are summarized. Further development of diagnostic criteria and procedures as well as international standardization of clinical diagnostics of extranodal extension should be encouraged. Several studies demonstrate that extranodal extension results in worse survival outcomes even in HPV-positive tumors, in contrast to results of previous studies. Consequently, whether the prognostic significance of extranodal extension is not actually relevant to outcome and the staging algorithm of HPV-positive OPSCC should be questioned and further analyzed. Frontiers Media S.A. 2020-08-11 /pmc/articles/PMC7433688/ /pubmed/32850449 http://dx.doi.org/10.3389/fonc.2020.01394 Text en Copyright © 2020 Beltz, Zimmer, Michaelides, Evert, Psychogios, Bohr and Künzel. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Beltz, Anna Zimmer, Stefanie Michaelides, Ioannis Evert, Katja Psychogios, Georgios Bohr, Christopher Künzel, Julian Significance of Extranodal Extension in Surgically Treated HPV-Positive Oropharyngeal Carcinomas |
title | Significance of Extranodal Extension in Surgically Treated HPV-Positive Oropharyngeal Carcinomas |
title_full | Significance of Extranodal Extension in Surgically Treated HPV-Positive Oropharyngeal Carcinomas |
title_fullStr | Significance of Extranodal Extension in Surgically Treated HPV-Positive Oropharyngeal Carcinomas |
title_full_unstemmed | Significance of Extranodal Extension in Surgically Treated HPV-Positive Oropharyngeal Carcinomas |
title_short | Significance of Extranodal Extension in Surgically Treated HPV-Positive Oropharyngeal Carcinomas |
title_sort | significance of extranodal extension in surgically treated hpv-positive oropharyngeal carcinomas |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433688/ https://www.ncbi.nlm.nih.gov/pubmed/32850449 http://dx.doi.org/10.3389/fonc.2020.01394 |
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