Beyond Single Nucleotide Polymorphisms: CYP3A5(∗)3(∗)6(∗)7 Composite and ABCB1 Haplotype Associations to Tacrolimus Pharmacokinetics in Black and White Renal Transplant Recipients

Interpatient variability in tacrolimus pharmacokinetics is attributed to metabolism by cytochrome P-450 3A5 (CYP3A5) isoenzymes and membrane transport by P-glycoprotein. Interpatient pharmacokinetic variability has been associated with genotypic variants for both CYP3A5 or ABCB1. Tacrolimus pharmaco...

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Detalles Bibliográficos
Autores principales: Brazeau, Daniel A., Attwood, Kristopher, Meaney, Calvin J., Wilding, Gregory E., Consiglio, Joseph D., Chang, Shirley S., Gundroo, Aijaz, Venuto, Rocco C., Cooper, Louise, Tornatore, Kathleen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433713/
https://www.ncbi.nlm.nih.gov/pubmed/32849848
http://dx.doi.org/10.3389/fgene.2020.00889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433713/
https://www.ncbi.nlm.nih.gov/pubmed/32849848
http://dx.doi.org/10.3389/fgene.2020.00889

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