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Comprehensive analysis of copy number variance and sensitivity to common targeted therapy in clear cell renal cell carcinoma: In silico analysis with in vitro validation

BACKGROUND: Chromosomal rearrangements are common in clear cell renal cell carcinoma (ccRCC) and their roles in mediating sensitivity to tyrosine kinase inhibitors (TKIs) and mTOR inhibitors (mTORi) remain elusive. METHODS: We developed an in silico strategy by screening copy number variance (CNV) t...

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Detalles Bibliográficos
Autores principales:	Li, Yuqing, Shen, Yanyun, Zhu, Zhidong, Wen, Hui, Feng, Chenchen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433817/ https://www.ncbi.nlm.nih.gov/pubmed/32628820 http://dx.doi.org/10.1002/cam4.3281

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