Cargando…

The semantic storage loss score: An Algorithm for measuring an individual's level of semantic storage loss due to temporal lobe damage in neurodegenerative disease

Anomia is common in Primary Progressive Aphasia (PPA), and there is considerable evidence that semantic problems (as opposed to impaired access to output word phonology) exist in many PPA individuals irrespective of their strict subtype, including a loss of representations from semantic memory, whic...

Descripción completa

Detalles Bibliográficos
Autores principales: Roncero, Carlos, Nikelski, Jim, Probst, Stephan, Fernandez, Alita, Thiel, Alex, Chertkow, Howard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433857/
https://www.ncbi.nlm.nih.gov/pubmed/32810171
http://dx.doi.org/10.1371/journal.pone.0235810
_version_ 1783572035169943552
author Roncero, Carlos
Nikelski, Jim
Probst, Stephan
Fernandez, Alita
Thiel, Alex
Chertkow, Howard
author_facet Roncero, Carlos
Nikelski, Jim
Probst, Stephan
Fernandez, Alita
Thiel, Alex
Chertkow, Howard
author_sort Roncero, Carlos
collection PubMed
description Anomia is common in Primary Progressive Aphasia (PPA), and there is considerable evidence that semantic problems (as opposed to impaired access to output word phonology) exist in many PPA individuals irrespective of their strict subtype, including a loss of representations from semantic memory, which is typical for people with the semantic variant of PPA. In this manuscript we present a straightforward novel clinical algorithm that quantifies this degree of semantic storage impairment. We sought to produce an algorithm by employing tasks that would measure key elements of semantic storage loss: a) whether an unrecalled name could be retrieved with cues; b) if performance for items was consistent across tasks; and c) the degree to which a participant’s performance was related to general severity of cognitive impairment rather than semantic loss. More specifically, these tasks were given to 28 individuals with PPA (12 participants had a clinical diagnosis of atypical Alzheimer’s Disease with the logopenic variant of PPA; the remaining 16 participants received a clinical diagnosis of Frontotemporal dementia (11 were classified as the non-fluent variant of PPA and five were the semantic variant of PPA). Scores from these tasks produced a single omnibus semantic memory storage loss score (SSL score) for each person that ranged from 0.0 to 1.0, with scores closer to 0 more indicative of semantic storage loss. Indeed, supporting the hypothesis that our scores measure the degree of semantic storage loss, we found participants with the semantic variant of PPA had the lowest scores, and SSL scores could predict the degree of hypometabolism in the anterior temporal lobe; even when only people with the logopenic variant of PPA were examined. Thus, these scores show promise quantitating the degree of a person’s semantic representation loss.
format Online
Article
Text
id pubmed-7433857
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-74338572020-08-20 The semantic storage loss score: An Algorithm for measuring an individual's level of semantic storage loss due to temporal lobe damage in neurodegenerative disease Roncero, Carlos Nikelski, Jim Probst, Stephan Fernandez, Alita Thiel, Alex Chertkow, Howard PLoS One Research Article Anomia is common in Primary Progressive Aphasia (PPA), and there is considerable evidence that semantic problems (as opposed to impaired access to output word phonology) exist in many PPA individuals irrespective of their strict subtype, including a loss of representations from semantic memory, which is typical for people with the semantic variant of PPA. In this manuscript we present a straightforward novel clinical algorithm that quantifies this degree of semantic storage impairment. We sought to produce an algorithm by employing tasks that would measure key elements of semantic storage loss: a) whether an unrecalled name could be retrieved with cues; b) if performance for items was consistent across tasks; and c) the degree to which a participant’s performance was related to general severity of cognitive impairment rather than semantic loss. More specifically, these tasks were given to 28 individuals with PPA (12 participants had a clinical diagnosis of atypical Alzheimer’s Disease with the logopenic variant of PPA; the remaining 16 participants received a clinical diagnosis of Frontotemporal dementia (11 were classified as the non-fluent variant of PPA and five were the semantic variant of PPA). Scores from these tasks produced a single omnibus semantic memory storage loss score (SSL score) for each person that ranged from 0.0 to 1.0, with scores closer to 0 more indicative of semantic storage loss. Indeed, supporting the hypothesis that our scores measure the degree of semantic storage loss, we found participants with the semantic variant of PPA had the lowest scores, and SSL scores could predict the degree of hypometabolism in the anterior temporal lobe; even when only people with the logopenic variant of PPA were examined. Thus, these scores show promise quantitating the degree of a person’s semantic representation loss. Public Library of Science 2020-08-18 /pmc/articles/PMC7433857/ /pubmed/32810171 http://dx.doi.org/10.1371/journal.pone.0235810 Text en © 2020 Roncero et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Roncero, Carlos
Nikelski, Jim
Probst, Stephan
Fernandez, Alita
Thiel, Alex
Chertkow, Howard
The semantic storage loss score: An Algorithm for measuring an individual's level of semantic storage loss due to temporal lobe damage in neurodegenerative disease
title The semantic storage loss score: An Algorithm for measuring an individual's level of semantic storage loss due to temporal lobe damage in neurodegenerative disease
title_full The semantic storage loss score: An Algorithm for measuring an individual's level of semantic storage loss due to temporal lobe damage in neurodegenerative disease
title_fullStr The semantic storage loss score: An Algorithm for measuring an individual's level of semantic storage loss due to temporal lobe damage in neurodegenerative disease
title_full_unstemmed The semantic storage loss score: An Algorithm for measuring an individual's level of semantic storage loss due to temporal lobe damage in neurodegenerative disease
title_short The semantic storage loss score: An Algorithm for measuring an individual's level of semantic storage loss due to temporal lobe damage in neurodegenerative disease
title_sort semantic storage loss score: an algorithm for measuring an individual's level of semantic storage loss due to temporal lobe damage in neurodegenerative disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433857/
https://www.ncbi.nlm.nih.gov/pubmed/32810171
http://dx.doi.org/10.1371/journal.pone.0235810
work_keys_str_mv AT roncerocarlos thesemanticstoragelossscoreanalgorithmformeasuringanindividualslevelofsemanticstoragelossduetotemporallobedamageinneurodegenerativedisease
AT nikelskijim thesemanticstoragelossscoreanalgorithmformeasuringanindividualslevelofsemanticstoragelossduetotemporallobedamageinneurodegenerativedisease
AT probststephan thesemanticstoragelossscoreanalgorithmformeasuringanindividualslevelofsemanticstoragelossduetotemporallobedamageinneurodegenerativedisease
AT fernandezalita thesemanticstoragelossscoreanalgorithmformeasuringanindividualslevelofsemanticstoragelossduetotemporallobedamageinneurodegenerativedisease
AT thielalex thesemanticstoragelossscoreanalgorithmformeasuringanindividualslevelofsemanticstoragelossduetotemporallobedamageinneurodegenerativedisease
AT chertkowhoward thesemanticstoragelossscoreanalgorithmformeasuringanindividualslevelofsemanticstoragelossduetotemporallobedamageinneurodegenerativedisease
AT roncerocarlos semanticstoragelossscoreanalgorithmformeasuringanindividualslevelofsemanticstoragelossduetotemporallobedamageinneurodegenerativedisease
AT nikelskijim semanticstoragelossscoreanalgorithmformeasuringanindividualslevelofsemanticstoragelossduetotemporallobedamageinneurodegenerativedisease
AT probststephan semanticstoragelossscoreanalgorithmformeasuringanindividualslevelofsemanticstoragelossduetotemporallobedamageinneurodegenerativedisease
AT fernandezalita semanticstoragelossscoreanalgorithmformeasuringanindividualslevelofsemanticstoragelossduetotemporallobedamageinneurodegenerativedisease
AT thielalex semanticstoragelossscoreanalgorithmformeasuringanindividualslevelofsemanticstoragelossduetotemporallobedamageinneurodegenerativedisease
AT chertkowhoward semanticstoragelossscoreanalgorithmformeasuringanindividualslevelofsemanticstoragelossduetotemporallobedamageinneurodegenerativedisease