3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors

Aberrant activation of the Wnt signalling pathway is required for tumour initiation and survival in the majority of colorectal cancers. The development of inhibitors of Wnt signalling has been the focus of multiple drug discovery programs targeting colorectal cancer and other malignancies associated...

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Detalles Bibliográficos
Autores principales: Badder, Luned M., Hollins, Andrew J., Herpers, Bram, Yan, Kuan, Ewan, Kenneth B., Thomas, Mairian, Shone, Jennifer R., Badder, Delyth A., Naven, Marc, Ashelford, Kevin E., Hargest, Rachel, Clarke, Alan R., Esdar, Christina, Buchstaller, Hans-Peter, Treherne, J. Mark, Boj, Sylvia, Ramezanpour, Bahar, Wienke, Dirk, Price, Leo S., Shaw, Paul H., Dale, Trevor C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433887/
https://www.ncbi.nlm.nih.gov/pubmed/32810173
http://dx.doi.org/10.1371/journal.pone.0235319

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