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Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells

Members of the family of pyrin and HIN domain containing (PYHIN) proteins play an emerging role in innate immunity. While absent in melanoma 2 (AIM2) acts a cytosolic sensor of non-self DNA and plays a key role in inflammasome assembly, the γ-interferon-inducible protein 16 (IFI16) restricts retrovi...

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Detalles Bibliográficos
Autores principales:	Bosso, Matteo, Prelli Bozzo, Caterina, Hotter, Dominik, Volcic, Meta, Stürzel, Christina M., Rammelt, Annika, Ni, Yi, Urban, Stephan, Becker, Miriam, Schelhaas, Mario, Wittmann, Sabine, Christensen, Maria H., Schmidt, Florian I., Gramberg, Thomas, Sparrer, Konstantin M. J., Sauter, Daniel, Kirchhoff, Frank
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433898/ https://www.ncbi.nlm.nih.gov/pubmed/32760121 http://dx.doi.org/10.1371/journal.ppat.1008752

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