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Tranexamic Acid in a Case Report of Life-threatening Nontraumatic Hemorrhage in Immune Thrombocytopenic Purpura
INTRODUCTION: Immune thrombocytopenic purpura (ITP) is an autoimmune-mediated disorder in which the body produces antibodies that destroy platelets, causing an increased risk of bleeding and bruising. Tranexamic acid (TXA) is a medication that prevents clot breakdown and is used to treat uncontrolle...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
University of California Irvine, Department of Emergency Medicine publishing Western Journal of Emergency Medicine
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434249/ https://www.ncbi.nlm.nih.gov/pubmed/32926702 http://dx.doi.org/10.5811/cpcem.2020.5.46955 |
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author | Randall, Melanie M. Nurse, Jason Singh, Karan P. |
author_facet | Randall, Melanie M. Nurse, Jason Singh, Karan P. |
author_sort | Randall, Melanie M. |
collection | PubMed |
description | INTRODUCTION: Immune thrombocytopenic purpura (ITP) is an autoimmune-mediated disorder in which the body produces antibodies that destroy platelets, causing an increased risk of bleeding and bruising. Tranexamic acid (TXA) is a medication that prevents clot breakdown and is used to treat uncontrolled bleeding. CASE REPORT: We present the case of an 11-year-old female with significant epistaxis and hypotension in the emergency department. Traditional therapies were initiated; however, the patient continued to have bleeding and remained hypotensive, so intravenous TXA was given. The patient’s bleeding then resolved. CONCLUSION: TXA may be a safe and effective adjunct to traditional therapies for the treatment of life-threatening hemorrhage in ITP patients. |
format | Online Article Text |
id | pubmed-7434249 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | University of California Irvine, Department of Emergency Medicine publishing Western Journal of Emergency Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-74342492020-08-20 Tranexamic Acid in a Case Report of Life-threatening Nontraumatic Hemorrhage in Immune Thrombocytopenic Purpura Randall, Melanie M. Nurse, Jason Singh, Karan P. Clin Pract Cases Emerg Med Case Report INTRODUCTION: Immune thrombocytopenic purpura (ITP) is an autoimmune-mediated disorder in which the body produces antibodies that destroy platelets, causing an increased risk of bleeding and bruising. Tranexamic acid (TXA) is a medication that prevents clot breakdown and is used to treat uncontrolled bleeding. CASE REPORT: We present the case of an 11-year-old female with significant epistaxis and hypotension in the emergency department. Traditional therapies were initiated; however, the patient continued to have bleeding and remained hypotensive, so intravenous TXA was given. The patient’s bleeding then resolved. CONCLUSION: TXA may be a safe and effective adjunct to traditional therapies for the treatment of life-threatening hemorrhage in ITP patients. University of California Irvine, Department of Emergency Medicine publishing Western Journal of Emergency Medicine 2020-07-09 /pmc/articles/PMC7434249/ /pubmed/32926702 http://dx.doi.org/10.5811/cpcem.2020.5.46955 Text en Copyright: © 2020 Randall et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) License. See: http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Case Report Randall, Melanie M. Nurse, Jason Singh, Karan P. Tranexamic Acid in a Case Report of Life-threatening Nontraumatic Hemorrhage in Immune Thrombocytopenic Purpura |
title | Tranexamic Acid in a Case Report of Life-threatening Nontraumatic Hemorrhage in Immune Thrombocytopenic Purpura |
title_full | Tranexamic Acid in a Case Report of Life-threatening Nontraumatic Hemorrhage in Immune Thrombocytopenic Purpura |
title_fullStr | Tranexamic Acid in a Case Report of Life-threatening Nontraumatic Hemorrhage in Immune Thrombocytopenic Purpura |
title_full_unstemmed | Tranexamic Acid in a Case Report of Life-threatening Nontraumatic Hemorrhage in Immune Thrombocytopenic Purpura |
title_short | Tranexamic Acid in a Case Report of Life-threatening Nontraumatic Hemorrhage in Immune Thrombocytopenic Purpura |
title_sort | tranexamic acid in a case report of life-threatening nontraumatic hemorrhage in immune thrombocytopenic purpura |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434249/ https://www.ncbi.nlm.nih.gov/pubmed/32926702 http://dx.doi.org/10.5811/cpcem.2020.5.46955 |
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