Could imiquimod (Aldara 5% cream) or other TLR7 agonists be used in the treatment of COVID-19?

Toll-like receptor 7 is critical in recognition of single strand RNA viruses, including SARS CoV-2, and generation of anti-viral immunity. Coronaviruses evolved strategies to dampen the host immunity. Herein, we discuss the potential use of TLR7 agonists in the early stages of COVID-19 treatment.

Detalles Bibliográficos
Autores principales: Avcilar, Huseyin, Eken, Ahmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434307/
https://www.ncbi.nlm.nih.gov/pubmed/33254510
http://dx.doi.org/10.1016/j.mehy.2020.110202
Descripción
Sumario:Toll-like receptor 7 is critical in recognition of single strand RNA viruses, including SARS CoV-2, and generation of anti-viral immunity. Coronaviruses evolved strategies to dampen the host immunity. Herein, we discuss the potential use of TLR7 agonists in the early stages of COVID-19 treatment.

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