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Interferon-λ at the Center of the Storm
Type I and III interferons (IFNs) drive effective antiviral functions but differentially affect tissue homeostasis. Using mouse models of severe inflammation, Broggi et al. and Major et al. report in Science that type III IFNs disrupt epithelial cell proliferation and differentiation in the lung.
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Inc.
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434483/ https://www.ncbi.nlm.nih.gov/pubmed/32814024 http://dx.doi.org/10.1016/j.immuni.2020.07.024 |
| _version_ | 1783572157319610368 |
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| author | Hendricks, Matthew R. Savan, Ram |
| author_facet | Hendricks, Matthew R. Savan, Ram |
| author_sort | Hendricks, Matthew R. |
| collection | PubMed |
| description | Type I and III interferons (IFNs) drive effective antiviral functions but differentially affect tissue homeostasis. Using mouse models of severe inflammation, Broggi et al. and Major et al. report in Science that type III IFNs disrupt epithelial cell proliferation and differentiation in the lung. |
| format | Online Article Text |
| id | pubmed-7434483 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Elsevier Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-74344832020-08-19 Interferon-λ at the Center of the Storm Hendricks, Matthew R. Savan, Ram Immunity Preview Type I and III interferons (IFNs) drive effective antiviral functions but differentially affect tissue homeostasis. Using mouse models of severe inflammation, Broggi et al. and Major et al. report in Science that type III IFNs disrupt epithelial cell proliferation and differentiation in the lung. Elsevier Inc. 2020-08-18 2020-08-18 /pmc/articles/PMC7434483/ /pubmed/32814024 http://dx.doi.org/10.1016/j.immuni.2020.07.024 Text en © 2020 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Preview Hendricks, Matthew R. Savan, Ram Interferon-λ at the Center of the Storm |
| title | Interferon-λ at the Center of the Storm |
| title_full | Interferon-λ at the Center of the Storm |
| title_fullStr | Interferon-λ at the Center of the Storm |
| title_full_unstemmed | Interferon-λ at the Center of the Storm |
| title_short | Interferon-λ at the Center of the Storm |
| title_sort | interferon-λ at the center of the storm |
| topic | Preview |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434483/ https://www.ncbi.nlm.nih.gov/pubmed/32814024 http://dx.doi.org/10.1016/j.immuni.2020.07.024 |
| work_keys_str_mv | AT hendricksmatthewr interferonlatthecenterofthestorm AT savanram interferonlatthecenterofthestorm |