Cervical Cancer: Emerging Immune Landscape and Treatment

Immune cells are essential for defending the body’s balance and have increasingly been implicated in controlling tumor growth. In cervical cancer (CC), the immune landscape is extensively connected with human papillomavirus (HPV) status. Recent insights from studies have revealed that as a result of...

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Detalles Bibliográficos
Autores principales: Guo, Luopei, Hua, Keqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434518/
https://www.ncbi.nlm.nih.gov/pubmed/32884290
http://dx.doi.org/10.2147/OTT.S264312
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author Guo, Luopei
Hua, Keqin
author_facet Guo, Luopei
Hua, Keqin
author_sort Guo, Luopei
collection PubMed
description Immune cells are essential for defending the body’s balance and have increasingly been implicated in controlling tumor growth. In cervical cancer (CC), the immune landscape is extensively connected with human papillomavirus (HPV) status. Recent insights from studies have revealed that as a result of infection with HPV, immune cell populations such as lymphocytes or monocytes change during carcinogenesis. Immune therapy, in particular checkpoint inhibitors, those targeting PD-1 or PD-L1, has shown promising efficacy. This article reviews the immune landscape and immunotherapy of CC.
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spelling pubmed-74345182020-09-02 Cervical Cancer: Emerging Immune Landscape and Treatment Guo, Luopei Hua, Keqin Onco Targets Ther Review Immune cells are essential for defending the body’s balance and have increasingly been implicated in controlling tumor growth. In cervical cancer (CC), the immune landscape is extensively connected with human papillomavirus (HPV) status. Recent insights from studies have revealed that as a result of infection with HPV, immune cell populations such as lymphocytes or monocytes change during carcinogenesis. Immune therapy, in particular checkpoint inhibitors, those targeting PD-1 or PD-L1, has shown promising efficacy. This article reviews the immune landscape and immunotherapy of CC. Dove 2020-08-12 /pmc/articles/PMC7434518/ /pubmed/32884290 http://dx.doi.org/10.2147/OTT.S264312 Text en © 2020 Guo and Hua. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Guo, Luopei
Hua, Keqin
Cervical Cancer: Emerging Immune Landscape and Treatment
title Cervical Cancer: Emerging Immune Landscape and Treatment
title_full Cervical Cancer: Emerging Immune Landscape and Treatment
title_fullStr Cervical Cancer: Emerging Immune Landscape and Treatment
title_full_unstemmed Cervical Cancer: Emerging Immune Landscape and Treatment
title_short Cervical Cancer: Emerging Immune Landscape and Treatment
title_sort cervical cancer: emerging immune landscape and treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434518/
https://www.ncbi.nlm.nih.gov/pubmed/32884290
http://dx.doi.org/10.2147/OTT.S264312
work_keys_str_mv AT guoluopei cervicalcanceremergingimmunelandscapeandtreatment
AT huakeqin cervicalcanceremergingimmunelandscapeandtreatment

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