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Ectopic Cortisol-producing Adrenocortical Adenoma Detected by 131I-6β-iodomethyl-norcholesterol Scintigraphy

A 50-year-old man was referred to our department for overt Cushing's syndrome (CS). His plasma cortisol concentrations were 314 μg/L, and his urinary cortisol concentrations were 431 μg/day. The plasma adrenocorticotropic hormone (ACTH) concentration was below the detectable limit. Computed tom...

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Autores principales: Sato, Seisuke, Imachi, Hitomi, Kobayashi, Toshihiro, Fukunaga, Kensaku, Lyu, Jingya, Dong, Tao, Yoshioka, Yuuki, Saheki, Takanobu, Fukata, Youko, Ban, Natsuki, Urushihara, Kurumi, Kadota, Kyuuichi, Murao, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434542/
https://www.ncbi.nlm.nih.gov/pubmed/32238722
http://dx.doi.org/10.2169/internalmedicine.4180-19
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author Sato, Seisuke
Imachi, Hitomi
Kobayashi, Toshihiro
Fukunaga, Kensaku
Lyu, Jingya
Dong, Tao
Yoshioka, Yuuki
Saheki, Takanobu
Fukata, Youko
Ban, Natsuki
Urushihara, Kurumi
Kadota, Kyuuichi
Murao, Koji
author_facet Sato, Seisuke
Imachi, Hitomi
Kobayashi, Toshihiro
Fukunaga, Kensaku
Lyu, Jingya
Dong, Tao
Yoshioka, Yuuki
Saheki, Takanobu
Fukata, Youko
Ban, Natsuki
Urushihara, Kurumi
Kadota, Kyuuichi
Murao, Koji
author_sort Sato, Seisuke
collection PubMed
description A 50-year-old man was referred to our department for overt Cushing's syndrome (CS). His plasma cortisol concentrations were 314 μg/L, and his urinary cortisol concentrations were 431 μg/day. The plasma adrenocorticotropic hormone (ACTH) concentration was below the detectable limit. Computed tomography revealed atrophy of both adrenal glands and the presence of a left pararenal tumor. 131I-6β-iodomethyl-norcholesterol scintigraphy showed an intense uptake by the left pararenal tumor. These findings suggested that the left pararenal tumor was ectopic cortisol-producing adrenocortical adenoma. This case serves as a reminder that 131I-6β-iodomethyl-norcholesterol scintigraphy is an effective method for diagnosing ACTH-independent CS in which no adrenal tumor has been found.
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spelling pubmed-74345422020-08-27 Ectopic Cortisol-producing Adrenocortical Adenoma Detected by 131I-6β-iodomethyl-norcholesterol Scintigraphy Sato, Seisuke Imachi, Hitomi Kobayashi, Toshihiro Fukunaga, Kensaku Lyu, Jingya Dong, Tao Yoshioka, Yuuki Saheki, Takanobu Fukata, Youko Ban, Natsuki Urushihara, Kurumi Kadota, Kyuuichi Murao, Koji Intern Med Case Report A 50-year-old man was referred to our department for overt Cushing's syndrome (CS). His plasma cortisol concentrations were 314 μg/L, and his urinary cortisol concentrations were 431 μg/day. The plasma adrenocorticotropic hormone (ACTH) concentration was below the detectable limit. Computed tomography revealed atrophy of both adrenal glands and the presence of a left pararenal tumor. 131I-6β-iodomethyl-norcholesterol scintigraphy showed an intense uptake by the left pararenal tumor. These findings suggested that the left pararenal tumor was ectopic cortisol-producing adrenocortical adenoma. This case serves as a reminder that 131I-6β-iodomethyl-norcholesterol scintigraphy is an effective method for diagnosing ACTH-independent CS in which no adrenal tumor has been found. The Japanese Society of Internal Medicine 2020-04-02 2020-07-15 /pmc/articles/PMC7434542/ /pubmed/32238722 http://dx.doi.org/10.2169/internalmedicine.4180-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sato, Seisuke
Imachi, Hitomi
Kobayashi, Toshihiro
Fukunaga, Kensaku
Lyu, Jingya
Dong, Tao
Yoshioka, Yuuki
Saheki, Takanobu
Fukata, Youko
Ban, Natsuki
Urushihara, Kurumi
Kadota, Kyuuichi
Murao, Koji
Ectopic Cortisol-producing Adrenocortical Adenoma Detected by 131I-6β-iodomethyl-norcholesterol Scintigraphy
title Ectopic Cortisol-producing Adrenocortical Adenoma Detected by 131I-6β-iodomethyl-norcholesterol Scintigraphy
title_full Ectopic Cortisol-producing Adrenocortical Adenoma Detected by 131I-6β-iodomethyl-norcholesterol Scintigraphy
title_fullStr Ectopic Cortisol-producing Adrenocortical Adenoma Detected by 131I-6β-iodomethyl-norcholesterol Scintigraphy
title_full_unstemmed Ectopic Cortisol-producing Adrenocortical Adenoma Detected by 131I-6β-iodomethyl-norcholesterol Scintigraphy
title_short Ectopic Cortisol-producing Adrenocortical Adenoma Detected by 131I-6β-iodomethyl-norcholesterol Scintigraphy
title_sort ectopic cortisol-producing adrenocortical adenoma detected by 131i-6β-iodomethyl-norcholesterol scintigraphy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434542/
https://www.ncbi.nlm.nih.gov/pubmed/32238722
http://dx.doi.org/10.2169/internalmedicine.4180-19
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