Cargando…

On-target versus off-target effects of drugs inhibiting the replication of SARS-CoV-2

The current epidemic of coronavirus disease-19 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) calls for the development of inhibitors of viral replication. Here, we performed a bioinformatic analysis of published and purported SARS-CoV-2 antivirals including imatin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sauvat, Allan, Ciccosanti, Fabiola, Colavita, Francesca, Di Rienzo, Martina, Castilletti, Concetta, Capobianchi, Maria Rosaria, Kepp, Oliver, Zitvogel, Laurence, Fimia, Gian Maria, Piacentini, Mauro, Kroemer, Guido
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434849/ https://www.ncbi.nlm.nih.gov/pubmed/32814759 http://dx.doi.org/10.1038/s41419-020-02842-x

Ejemplares similares

Proteomic analysis identifies the RNA helicase DDX3X as a host target against SARS-CoV-2 infection
por: Ciccosanti, Fabiola, et al.
Publicado: (2021)

A microRNA Arising from the Negative Strand of SARS-CoV-2 Genome Targets FOS to Reduce AP-1 Activity
por: Greco, Francesco, et al.
Publicado: (2023)

Mitochondrial Interactome: A Focus on Antiviral Signaling Pathways
por: Refolo, Giulia, et al.
Publicado: (2020)

AMBRA1 regulates mitophagy by interacting with ATAD3A and promoting PINK1 stability
por: Di Rienzo, Martina, et al.
Publicado: (2021)

Type 2 transglutaminase in the nucleus: the new epigenetic face of a cytoplasmic enzyme
por: Rossin, Federica, et al.
Publicado: (2023)

An unexpected link between immunogenic cell death and inhibition of gene transcription
por: Humeau, Juliette, et al.
Publicado: (2020)

Lurbinectedin: an FDA-approved inducer of immunogenic cell death for the treatment of small-cell lung cancer
por: Kepp, Oliver, et al.
Publicado: (2020)

Prevention and treatment of cancers by tumor antigen-expressing Staphylococcus epidermidis
por: Kepp, Oliver, et al.
Publicado: (2023)

Polio is back? The risk of poliomyelitis recurrence globally, and the legacy of the severe acute respiratory syndrome coronavirus 2 pandemic
por: Castilletti, Concetta, et al.
Publicado: (2023)

Targeting PD-1/PD-L1 interactions for cancer immunotherapy
por: Zitvogel, Laurence, et al.
Publicado: (2012)

Inhibition of autophagy in EBV-positive Burkitt's lymphoma cells enhances EBV lytic genes expression and replication
por: De Leo, A, et al.
Publicado: (2015)

Tumor-infiltrating lymphocytes for melanoma immunotherapy
por: Kepp, Oliver, et al.
Publicado: (2023)

The oncolytic peptide LTX-315 kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization
por: Zhou, Heng, et al.
Publicado: (2015)

Bcl-2 inhibits the caspase-dependent apoptosis induced by SARS-CoV without affecting virus replication kinetics
por: Bordi, L., et al.
Publicado: (2005)

Analysis of Secreted Proteins from Prepubertal Ovarian Tissues Exposed In Vitro to Cisplatin and LH
por: Marcozzi, Serena, et al.
Publicado: (2022)

Immunogenicity and safety of BNT162b2 COVID‐19 vaccine in a chronic lymphocytic leukaemia patient
por: Agrati, Chiara, et al.
Publicado: (2021)

Trial Watch: combination of tyrosine kinase inhibitors (TKIs) and immunotherapy
por: Petrazzuolo, Adriana, et al.
Publicado: (2022)

Multi-omics approach to COVID-19: a domain-based literature review
por: Montaldo, Chiara, et al.
Publicado: (2021)

Evidences for lipid involvement in SARS-CoV-2 cytopathogenesis
por: Nardacci, Roberta, et al.
Publicado: (2021)

In Vitro Models for Studying Entry, Tissue Tropism, and Therapeutic Approaches of Highly Pathogenic Coronaviruses
por: Najafi Fard, Saeid, et al.
Publicado: (2021)

Tropism of the Chikungunya Virus
por: Matusali, Giulia, et al.
Publicado: (2019)

Performance evaluation of Abbott ARCHITECT SARS-CoV-2 IgG immunoassay in comparison with indirect immunofluorescence and virus microneutralization test
por: Meschi, Silvia, et al.
Publicado: (2020)

Inhibition of transcription by dactinomycin reveals a new characteristic of immunogenic cell stress
por: Humeau, Juliette, et al.
Publicado: (2020)

Iron overload down-regulates the expression of the HIV-1 Rev cofactor eIF5A in infected T lymphocytes
por: Mancone, Carmine, et al.
Publicado: (2017)

AKT as a therapeutic target for autophagy induction and cancer therapy
por: Wu, Qi, et al.
Publicado: (2021)

Autophagy in HCV Infection: Keeping Fat and Inflammation at Bay
por: Vescovo, Tiziana, et al.
Publicado: (2014)

An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells
por: Senovilla, Laura, et al.
Publicado: (2013)

Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope
por: Perfettini, Jean-Luc, et al.
Publicado: (2005)

Saliva Is a Valid Alternative to Nasopharyngeal Swab in Chemiluminescence-Based Assay for Detection of SARS-CoV-2 Antigen
por: Amendola, Alessandra, et al.
Publicado: (2021)

Synthetic induction of immunogenic cell death by genetic stimulation of endoplasmic reticulum stress
por: Michaud, Mickaël, et al.
Publicado: (2014)

PD-1 blockade synergizes with oxaliplatin-based, but not cisplatin-based, chemotherapy of gastric cancer
por: Liu, Peng, et al.
Publicado: (2022)

Antibody–drug conjugates harboring a kinesin spindle protein inhibitor with immunostimulatory properties
por: Sommer, Anette, et al.
Publicado: (2022)

The interplay between SARS-CoV-2 infected airway epithelium and immune cells modulates regulatory/inflammatory signals
por: Bordoni, Veronica, et al.
Publicado: (2022)

Inflammatory and Humoral Immune Response during Ebola Virus Infection in Survivor and Fatal Cases Occurred in Sierra Leone during the 2014–2016 Outbreak in West Africa
por: Colavita, Francesca, et al.
Publicado: (2019)

Quantification of cellular viability by automated microscopy and flow cytometry
por: Sauvat, Allan, et al.
Publicado: (2015)

Coordinate induction of IFN-α and -γ by SARS-CoV also in the absence of virus replication
por: Castilletti, Concetta, et al.
Publicado: (2005)

Everolimus and plicamycin specifically target chemoresistant colorectal cancer cells of the CMS4 subtype
por: Deng, Jiayin, et al.
Publicado: (2021)

ZIKV Infection Induces an Inflammatory Response but Fails to Activate Types I, II, and III IFN Response in Human PBMC
por: Colavita, Francesca, et al.
Publicado: (2018)

Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak
por: Colavita, Francesca, et al.
Publicado: (2018)

Abscopal but desirable: The contribution of immune responses to the efficacy of radiotherapy
por: Kroemer, Guido, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_22qsn59uie8r45a5qdm5372p50