Comparison of nonhuman primates identified the suitable model for COVID-19

Identification of a suitable nonhuman primate (NHP) model of COVID-19 remains challenging. Here, we characterized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in three NHP species: Old World monkeys Macaca mulatta (M. mulatta) and Macaca fascicularis (M. fascicularis) and N...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Shuaiyao, Zhao, Yuan, Yu, Wenhai, Yang, Yun, Gao, Jiahong, Wang, Junbin, Kuang, Dexuan, Yang, Mengli, Yang, Jing, Ma, Chunxia, Xu, Jingwen, Qian, Xingli, Li, Haiyan, Zhao, Siwen, Li, Jingmei, Wang, Haixuan, Long, Haiting, Zhou, Jingxian, Luo, Fangyu, Ding, Kaiyun, Wu, Daoju, Zhang, Yong, Dong, Yinliang, Liu, Yuqin, Zheng, Yinqiu, Lin, Xiaochen, Jiao, Li, Zheng, Huanying, Dai, Qing, Sun, Qiangming, Hu, Yunzhang, Ke, Changwen, Liu, Hongqi, Peng, Xiaozhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434851/
https://www.ncbi.nlm.nih.gov/pubmed/32814760
http://dx.doi.org/10.1038/s41392-020-00269-6
_version_ 1783572222509580288
author Lu, Shuaiyao
Zhao, Yuan
Yu, Wenhai
Yang, Yun
Gao, Jiahong
Wang, Junbin
Kuang, Dexuan
Yang, Mengli
Yang, Jing
Ma, Chunxia
Xu, Jingwen
Qian, Xingli
Li, Haiyan
Zhao, Siwen
Li, Jingmei
Wang, Haixuan
Long, Haiting
Zhou, Jingxian
Luo, Fangyu
Ding, Kaiyun
Wu, Daoju
Zhang, Yong
Dong, Yinliang
Liu, Yuqin
Zheng, Yinqiu
Lin, Xiaochen
Jiao, Li
Zheng, Huanying
Dai, Qing
Sun, Qiangming
Hu, Yunzhang
Ke, Changwen
Liu, Hongqi
Peng, Xiaozhong
author_facet Lu, Shuaiyao
Zhao, Yuan
Yu, Wenhai
Yang, Yun
Gao, Jiahong
Wang, Junbin
Kuang, Dexuan
Yang, Mengli
Yang, Jing
Ma, Chunxia
Xu, Jingwen
Qian, Xingli
Li, Haiyan
Zhao, Siwen
Li, Jingmei
Wang, Haixuan
Long, Haiting
Zhou, Jingxian
Luo, Fangyu
Ding, Kaiyun
Wu, Daoju
Zhang, Yong
Dong, Yinliang
Liu, Yuqin
Zheng, Yinqiu
Lin, Xiaochen
Jiao, Li
Zheng, Huanying
Dai, Qing
Sun, Qiangming
Hu, Yunzhang
Ke, Changwen
Liu, Hongqi
Peng, Xiaozhong
author_sort Lu, Shuaiyao
collection PubMed
description Identification of a suitable nonhuman primate (NHP) model of COVID-19 remains challenging. Here, we characterized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in three NHP species: Old World monkeys Macaca mulatta (M. mulatta) and Macaca fascicularis (M. fascicularis) and New World monkey Callithrix jacchus (C. jacchus). Infected M. mulatta and M. fascicularis showed abnormal chest radiographs, an increased body temperature and a decreased body weight. Viral genomes were detected in swab and blood samples from all animals. Viral load was detected in the pulmonary tissues of M. mulatta and M. fascicularis but not C. jacchus. Furthermore, among the three animal species, M. mulatta showed the strongest response to SARS-CoV-2, including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues. Collectively, these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M. mulatta as the most suitable for modeling COVID-19.
format Online
Article
Text
id pubmed-7434851
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-74348512020-08-24 Comparison of nonhuman primates identified the suitable model for COVID-19 Lu, Shuaiyao Zhao, Yuan Yu, Wenhai Yang, Yun Gao, Jiahong Wang, Junbin Kuang, Dexuan Yang, Mengli Yang, Jing Ma, Chunxia Xu, Jingwen Qian, Xingli Li, Haiyan Zhao, Siwen Li, Jingmei Wang, Haixuan Long, Haiting Zhou, Jingxian Luo, Fangyu Ding, Kaiyun Wu, Daoju Zhang, Yong Dong, Yinliang Liu, Yuqin Zheng, Yinqiu Lin, Xiaochen Jiao, Li Zheng, Huanying Dai, Qing Sun, Qiangming Hu, Yunzhang Ke, Changwen Liu, Hongqi Peng, Xiaozhong Signal Transduct Target Ther Article Identification of a suitable nonhuman primate (NHP) model of COVID-19 remains challenging. Here, we characterized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in three NHP species: Old World monkeys Macaca mulatta (M. mulatta) and Macaca fascicularis (M. fascicularis) and New World monkey Callithrix jacchus (C. jacchus). Infected M. mulatta and M. fascicularis showed abnormal chest radiographs, an increased body temperature and a decreased body weight. Viral genomes were detected in swab and blood samples from all animals. Viral load was detected in the pulmonary tissues of M. mulatta and M. fascicularis but not C. jacchus. Furthermore, among the three animal species, M. mulatta showed the strongest response to SARS-CoV-2, including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues. Collectively, these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M. mulatta as the most suitable for modeling COVID-19. Nature Publishing Group UK 2020-10-19 /pmc/articles/PMC7434851/ /pubmed/32814760 http://dx.doi.org/10.1038/s41392-020-00269-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lu, Shuaiyao
Zhao, Yuan
Yu, Wenhai
Yang, Yun
Gao, Jiahong
Wang, Junbin
Kuang, Dexuan
Yang, Mengli
Yang, Jing
Ma, Chunxia
Xu, Jingwen
Qian, Xingli
Li, Haiyan
Zhao, Siwen
Li, Jingmei
Wang, Haixuan
Long, Haiting
Zhou, Jingxian
Luo, Fangyu
Ding, Kaiyun
Wu, Daoju
Zhang, Yong
Dong, Yinliang
Liu, Yuqin
Zheng, Yinqiu
Lin, Xiaochen
Jiao, Li
Zheng, Huanying
Dai, Qing
Sun, Qiangming
Hu, Yunzhang
Ke, Changwen
Liu, Hongqi
Peng, Xiaozhong
Comparison of nonhuman primates identified the suitable model for COVID-19
title Comparison of nonhuman primates identified the suitable model for COVID-19
title_full Comparison of nonhuman primates identified the suitable model for COVID-19
title_fullStr Comparison of nonhuman primates identified the suitable model for COVID-19
title_full_unstemmed Comparison of nonhuman primates identified the suitable model for COVID-19
title_short Comparison of nonhuman primates identified the suitable model for COVID-19
title_sort comparison of nonhuman primates identified the suitable model for covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434851/
https://www.ncbi.nlm.nih.gov/pubmed/32814760
http://dx.doi.org/10.1038/s41392-020-00269-6
work_keys_str_mv AT lushuaiyao comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT zhaoyuan comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT yuwenhai comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT yangyun comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT gaojiahong comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT wangjunbin comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT kuangdexuan comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT yangmengli comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT yangjing comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT machunxia comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT xujingwen comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT qianxingli comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT lihaiyan comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT zhaosiwen comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT lijingmei comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT wanghaixuan comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT longhaiting comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT zhoujingxian comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT luofangyu comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT dingkaiyun comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT wudaoju comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT zhangyong comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT dongyinliang comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT liuyuqin comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT zhengyinqiu comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT linxiaochen comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT jiaoli comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT zhenghuanying comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT daiqing comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT sunqiangming comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT huyunzhang comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT kechangwen comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT liuhongqi comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19
AT pengxiaozhong comparisonofnonhumanprimatesidentifiedthesuitablemodelforcovid19

Ejemplares similares