Cargando…

Regorafenib is effective against neuroblastoma in vitro and in vivo and inhibits the RAS/MAPK, PI3K/Akt/mTOR and Fos/Jun pathways

BACKGROUND: Regorafenib is an inhibitor of multiple kinases with aberrant expression and activity in neuroblastoma tumours that have potential roles in neuroblastoma pathogenesis. METHODS: We evaluated neuroblastoma cells treated with regorafenib for cell viability and confluence, and analysed treat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Subramonian, Divya, Phanhthilath, Nikki, Rinehardt, Hannah, Flynn, Sean, Huo, Yuchen, Zhang, Jing, Messer, Karen, Mo, Qianxing, Huang, Shixia, Lesperance, Jacqueline, Zage, Peter E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434894/ https://www.ncbi.nlm.nih.gov/pubmed/32457362 http://dx.doi.org/10.1038/s41416-020-0905-8

Ejemplares similares

The multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo
por: Flynn, Sean M., et al.
Publicado: (2019)

UBE4B interacts with the ITCH E3 ubiquitin ligase to induce Ku70 and c-FLIPL polyubiquitination and enhanced neuroblastoma apoptosis
por: Le Clorennec, Christophe, et al.
Publicado: (2023)

The Potential Functional Roles of NME1 Histidine Kinase Activity in Neuroblastoma Pathogenesis
por: Adam, Kevin, et al.
Publicado: (2020)

Strong and prolonged induction of c-jun and c-fos proto-oncogenes by photodynamic therapy.
por: Kick, G., et al.
Publicado: (1996)

Selection and Characterization of a DNA Aptamer That Can Discriminate between cJun/cJun and cJun/cFos
por: Walters, Ryan D., et al.
Publicado: (2014)

Novel Therapies for Relapsed and Refractory Neuroblastoma
por: Zage, Peter E.
Publicado: (2018)

Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease
por: Zenz, Rainer, et al.
Publicado: (2008)

In Silico Inhibition Studies of Jun-Fos-DNA Complex Formation by Curcumin Derivatives
por: Kumar, Anil, et al.
Publicado: (2012)

Barriers to transmission of transcriptional noise in a c-fos c-jun pathway
por: Shah, Khyati, et al.
Publicado: (2013)

Allele-specific expression reveals genes with recurrent cis-regulatory alterations in high-risk neuroblastoma
por: Sen, Arko, et al.
Publicado: (2022)

USP7 Inhibition Suppresses Neuroblastoma Growth via Induction of p53-Mediated Apoptosis and EZH2 and N-Myc Downregulation
por: Le Clorennec, Christophe, et al.
Publicado: (2023)

The Expression Patterns of c-Fos and c-Jun Induced by Different Frequencies of Electroacupuncture in the Brain
por: Qiu, Zheng-Ying, et al.
Publicado: (2015)

JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer
por: Ruiz, E. Josue, et al.
Publicado: (2021)

Trans-repressor activity of nuclear glycosaminoglycans on Fos and Jun/AP-1 oncoprotein-mediated transcription
Publicado: (1992)

DT-diaphorase activity in NSCLC and SCLC cell lines: a role for fos/jun regulation
por: Kepa, J K, et al.
Publicado: (1999)

A modified version of a Fos-associated cluster in HBZ affects Jun transcriptional potency
por: Hivin, Patrick, et al.
Publicado: (2006)

Products of the fos and jun proto-oncogenes bind cooperatively to the AP1 DNA recognition sequence.
por: Risse, G, et al.
Publicado: (1990)

Interleukin‐6 regulates expression of Fos and Jun genes to affect the development of mouse preimplantation embryos
por: Yu, Chunhua, et al.
Publicado: (2017)

Regulation of Jun and Fos AP-1 transcription factors by JNK MAPKs signaling cascade in areca nut extract treated KB cells
por: Nagesh, Rashmi, et al.
Publicado: (2021)

A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma
por: Mlakar, Vid, et al.
Publicado: (2021)

FOS Rescues Neuronal Differentiation of Sox2-Deleted Neural Stem Cells by Genome-Wide Regulation of Common SOX2 and AP1(FOS-JUN) Target Genes
por: Pagin, Miriam, et al.
Publicado: (2021)

Activation of the neu tyrosine kinase induces the fos/jun transcription factor complex, the glucose transporter and ornithine decarboxylase
Publicado: (1989)

Discrepancy between jun/fos proto-oncogene mRNA and protein expression in the rheumatoid arthritis synovial membrane
por: Huber, R, et al.
Publicado: (2005)

IL-3-Induced Immediate Expression of c-fos and c-jun Is Modulated by the IKK2-JNK Axis
por: Fujita, Hirotaka, et al.
Publicado: (2022)

In vitro and in vivo study of the expression of the Syk/Ras/c-Fos pathway in chronic glomerulonephritis
por: Gao, Jiarong, et al.
Publicado: (2018)

Characterization of G-CSF receptor expression in medulloblastoma
por: Paul, Megan Rose, et al.
Publicado: (2020)

Neuroblastoma patient outcomes, tumor differentiation, and ERK activation are correlated with expression levels of the ubiquitin ligase UBE4B
por: Woodfield, Sarah E., et al.
Publicado: (2016)

Transcriptional Regulation by Gold(I) Thiolates Involving Interaction With Conserved Cysteine Residues in the Photo-Oncogene Products Jun and Fos
por: Handel, Malcolm L., et al.
Publicado: (1994)

Prognostic value of ERBB-1, VEGF, cyclin A, FOS, JUN and MYC in patients with squamous cell lung carcinomas
Publicado: (1998)

Prognostic value of ERBB-1, VEGF, cyclin A, FOS, JUN and MYC in patients with squamous cell lung carcinomas.
por: Volm, M., et al.
Publicado: (1998)

The Function of Heterodimeric AP-1 Comprised of c-Jun and c-Fos in Activin Mediated Spemann Organizer Gene Expression
por: Lee, Sung-Young, et al.
Publicado: (2011)

Immediate expression of c-fos and c-jun mRNA in a model of intestinal autotransplantation and ischemia-reperfusion in situ
por: Santos, Maria Mercês, et al.
Publicado: (2015)

Expression of CCL2, FOS, and JUN May Help to Distinguish Patients With IgA Nephropathy From Healthy Controls
por: Zhou, Xue, et al.
Publicado: (2022)

Transcriptional activation of Jun and Fos members of the AP‐1 complex is a conserved signature of immune aging that contributes to inflammaging
por: Karakaslar, Emin Onur, et al.
Publicado: (2023)

Small molecule inhibitor regorafenib inhibits RET signaling in neuroblastoma cells and effectively suppresses tumor growth in vivo
por: Chen, Zhenghu, et al.
Publicado: (2017)

Neuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis
por: Zheng, Kang, et al.
Publicado: (2023)

Inhibition of growth of OV-1063 human epithelial ovarian cancers and c- jun and c- fos oncogene expression by bombesin antagonists
por: Chatzistamou, I, et al.
Publicado: (2000)

Dynamic Acetylation of All Lysine 4–Methylated Histone H3 in the Mouse Nucleus: Analysis at c-fos and c-jun
por: Hazzalin, Catherine A, et al.
Publicado: (2005)

Imaging Fos-Jun Transcription Factor Mobility and Interaction in Live Cells by Single Plane Illumination-Fluorescence Cross Correlation Spectroscopy
por: Pernuš, Agata, et al.
Publicado: (2015)

Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer
por: Gupta, Shilpi, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_pkudlvoflatkf27m5b65ba0dq4