Chlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of FLT3-ITD and KIT-D816V

Mutated receptor tyrosine kinases (MT-RTKs) such as internal tandem duplication of FMS-like tyrosine kinase 3 (FLT3 ITD) and a point mutation KIT D816V are driver mutations for acute myeloid leukemia (AML). Clathrin assembly lymphoid myeloid leukemia protein (CALM) regulates intracellular transport...

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Detalles Bibliográficos
Autores principales: Rai, Shinya, Tanaka, Hirokazu, Suzuki, Mai, Espinoza, J. Luis, Kumode, Takahiro, Tanimura, Akira, Yokota, Takafumi, Oritani, Kenji, Watanabe, Toshio, Kanakura, Yuzuru, Matsumura, Itaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434901/
https://www.ncbi.nlm.nih.gov/pubmed/32811837
http://dx.doi.org/10.1038/s41467-020-17666-8

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