Proteomic analysis links alterations of bioenergetics, mitochondria-ER interactions and proteostasis in hippocampal astrocytes from 3xTg-AD mice

The pathogenesis of Alzheimer’s disease (AD), a slowly-developing age-related neurodegenerative disorder, is a result of the action of multiple factors including deregulation of Ca(2+) homeostasis, mitochondrial dysfunction, and dysproteostasis. Interaction of these factors in astrocytes, principal...

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Detalles Bibliográficos
Autores principales: Dematteis, Giulia, Vydmantaitė, Gabrielė, Ruffinatti, Federico Alessandro, Chahin, Malak, Farruggio, Serena, Barberis, Elettra, Ferrari, Eleonora, Marengo, Emilio, Distasi, Carla, Morkūnienė, Ramunė, Genazzani, Armando A., Grilli, Mariagrazia, Grossini, Elena, Corazzari, Marco, Manfredi, Marcello, Lim, Dmitry, Jekabsone, Aistė, Tapella, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434916/
https://www.ncbi.nlm.nih.gov/pubmed/32811809
http://dx.doi.org/10.1038/s41419-020-02911-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434916/
https://www.ncbi.nlm.nih.gov/pubmed/32811809
http://dx.doi.org/10.1038/s41419-020-02911-1

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