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Using Relaxation Time to characterize biological effects of different mutagens

All kinds of mutagenic factors may cause physiological, biochemical and genetic changes of all organisms. To characterize their characteristic biology effects, the concept of Relaxation Time (RT) was introduced for the first time, and the specific process was as follows. After mutation of organisms,...

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Autores principales: Li, Xinglin, Sun, Shuguang, Yao, Jingxia, Sun, Zhengfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434921/
https://www.ncbi.nlm.nih.gov/pubmed/32811881
http://dx.doi.org/10.1038/s41598-020-70600-2
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author Li, Xinglin
Sun, Shuguang
Yao, Jingxia
Sun, Zhengfeng
author_facet Li, Xinglin
Sun, Shuguang
Yao, Jingxia
Sun, Zhengfeng
author_sort Li, Xinglin
collection PubMed
description All kinds of mutagenic factors may cause physiological, biochemical and genetic changes of all organisms. To characterize their characteristic biology effects, the concept of Relaxation Time (RT) was introduced for the first time, and the specific process was as follows. After mutation of organisms, the offsprings will be continuingly cultured (or cultivated) to the next generation (Rx). Once a biological effect began to show no significant difference compared to the untreated controls, the Rx was defined as the RT of the effect. In this paper, three kinds of mutagenic factors were selected to treat the seeds or seedlings of Astragalus sinicus L., subsequently, the corresponding RT was calibrated. The results showed that the RT was diverse not only among different biological effects but also among different mutagenic factors. For the RT of chemical mutagens and gamma rays, most of which are concentrated on R(1), whereas the heavy ion beams have significant differences among different tracks. Among biological effects, the SOD activity and superoxide anion free radical content in the Peak region are more prominent, and their RT reaches R(3) and R(4), respectively. Thus, the RT may characterize the characteristic biological effects from differently mutagenic factors.
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spelling pubmed-74349212020-08-21 Using Relaxation Time to characterize biological effects of different mutagens Li, Xinglin Sun, Shuguang Yao, Jingxia Sun, Zhengfeng Sci Rep Article All kinds of mutagenic factors may cause physiological, biochemical and genetic changes of all organisms. To characterize their characteristic biology effects, the concept of Relaxation Time (RT) was introduced for the first time, and the specific process was as follows. After mutation of organisms, the offsprings will be continuingly cultured (or cultivated) to the next generation (Rx). Once a biological effect began to show no significant difference compared to the untreated controls, the Rx was defined as the RT of the effect. In this paper, three kinds of mutagenic factors were selected to treat the seeds or seedlings of Astragalus sinicus L., subsequently, the corresponding RT was calibrated. The results showed that the RT was diverse not only among different biological effects but also among different mutagenic factors. For the RT of chemical mutagens and gamma rays, most of which are concentrated on R(1), whereas the heavy ion beams have significant differences among different tracks. Among biological effects, the SOD activity and superoxide anion free radical content in the Peak region are more prominent, and their RT reaches R(3) and R(4), respectively. Thus, the RT may characterize the characteristic biological effects from differently mutagenic factors. Nature Publishing Group UK 2020-08-18 /pmc/articles/PMC7434921/ /pubmed/32811881 http://dx.doi.org/10.1038/s41598-020-70600-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Li, Xinglin
Sun, Shuguang
Yao, Jingxia
Sun, Zhengfeng
Using Relaxation Time to characterize biological effects of different mutagens
title Using Relaxation Time to characterize biological effects of different mutagens
title_full Using Relaxation Time to characterize biological effects of different mutagens
title_fullStr Using Relaxation Time to characterize biological effects of different mutagens
title_full_unstemmed Using Relaxation Time to characterize biological effects of different mutagens
title_short Using Relaxation Time to characterize biological effects of different mutagens
title_sort using relaxation time to characterize biological effects of different mutagens
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434921/
https://www.ncbi.nlm.nih.gov/pubmed/32811881
http://dx.doi.org/10.1038/s41598-020-70600-2
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