Molecular docking analysis of piperine with CDK2,CDK4,Cyclin D and Cyclin T proteins

Piperine is a component of Piper nigrum (Black pepper). It is well known in ayurvedic formulations. Piperine is a bioenhancer as it reduces the activity of drug-metabolizing enzymes in rodents and thereby enhancing the plasma concentrations of several drugs, including the Pglycoprotein substrates. T...

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Autores principales: Rekha, Umapathy Vidhya, Anita, M, Jayamathi, Govindaraj, Sadhana, K, Deepa, Subramanian, Hussain, Sajid, Bhuvaneswari, J, Ramya, V, Selvaraj, Jayaraman, Naveenraj, NS
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2020
Materias:
Research-Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434954/
https://www.ncbi.nlm.nih.gov/pubmed/32831516
http://dx.doi.org/10.6026/97320630016359
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author Rekha, Umapathy Vidhya
Anita, M
Jayamathi, Govindaraj
Sadhana, K
Deepa, Subramanian
Hussain, Sajid
Bhuvaneswari, J
Ramya, V
Selvaraj, Jayaraman
Naveenraj, NS
author_facet Rekha, Umapathy Vidhya
Anita, M
Jayamathi, Govindaraj
Sadhana, K
Deepa, Subramanian
Hussain, Sajid
Bhuvaneswari, J
Ramya, V
Selvaraj, Jayaraman
Naveenraj, NS
author_sort Rekha, Umapathy Vidhya
collection PubMed
description Piperine is a component of Piper nigrum (Black pepper). It is well known in ayurvedic formulations. Piperine is a bioenhancer as it reduces the activity of drug-metabolizing enzymes in rodents and thereby enhancing the plasma concentrations of several drugs, including the Pglycoprotein substrates. Therefore, it is of interest to understand the molecular docking interactions of piperine with several cell cycle proteins such as Cyclin dependent kinase 2 (CDK2), Cyclin-dependent kinase 4 (CDK4), Cyclin D and Cyclin T for further consideration in drug discovery related to oral cancer.
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spelling pubmed-74349542020-08-21 Molecular docking analysis of piperine with CDK2,CDK4,Cyclin D and Cyclin T proteins Rekha, Umapathy Vidhya Anita, M Jayamathi, Govindaraj Sadhana, K Deepa, Subramanian Hussain, Sajid Bhuvaneswari, J Ramya, V Selvaraj, Jayaraman Naveenraj, NS Bioinformation Research-Article Piperine is a component of Piper nigrum (Black pepper). It is well known in ayurvedic formulations. Piperine is a bioenhancer as it reduces the activity of drug-metabolizing enzymes in rodents and thereby enhancing the plasma concentrations of several drugs, including the Pglycoprotein substrates. Therefore, it is of interest to understand the molecular docking interactions of piperine with several cell cycle proteins such as Cyclin dependent kinase 2 (CDK2), Cyclin-dependent kinase 4 (CDK4), Cyclin D and Cyclin T for further consideration in drug discovery related to oral cancer. Biomedical Informatics 2020-05-31 /pmc/articles/PMC7434954/ /pubmed/32831516 http://dx.doi.org/10.6026/97320630016359 Text en © 2020 Biomedical Informatics http://creativecommons.org/licenses/by/3.0/ This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research-Article
Rekha, Umapathy Vidhya
Anita, M
Jayamathi, Govindaraj
Sadhana, K
Deepa, Subramanian
Hussain, Sajid
Bhuvaneswari, J
Ramya, V
Selvaraj, Jayaraman
Naveenraj, NS
Molecular docking analysis of piperine with CDK2,CDK4,Cyclin D and Cyclin T proteins
title Molecular docking analysis of piperine with CDK2,CDK4,Cyclin D and Cyclin T proteins
title_full Molecular docking analysis of piperine with CDK2,CDK4,Cyclin D and Cyclin T proteins
title_fullStr Molecular docking analysis of piperine with CDK2,CDK4,Cyclin D and Cyclin T proteins
title_full_unstemmed Molecular docking analysis of piperine with CDK2,CDK4,Cyclin D and Cyclin T proteins
title_short Molecular docking analysis of piperine with CDK2,CDK4,Cyclin D and Cyclin T proteins
title_sort molecular docking analysis of piperine with cdk2,cdk4,cyclin d and cyclin t proteins
topic Research-Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434954/
https://www.ncbi.nlm.nih.gov/pubmed/32831516
http://dx.doi.org/10.6026/97320630016359
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