A report on DNA sequence determinants in gene expression

The biased usage of nucleotides in coding sequence and its correlation with gene expression has been observed in several studies. A complex set of interactions between genes and other components of the expression system determine the amount of proteins produced from coding sequences. It is known tha...

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Detalles Bibliográficos
Autores principales: Singh, Ravail, Sophiarani, Yengkhom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2020
Materias:
Research-Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434957/
https://www.ncbi.nlm.nih.gov/pubmed/32831525
http://dx.doi.org/10.6026/97320630016422
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author Singh, Ravail
Sophiarani, Yengkhom
author_facet Singh, Ravail
Sophiarani, Yengkhom
author_sort Singh, Ravail
collection PubMed
description The biased usage of nucleotides in coding sequence and its correlation with gene expression has been observed in several studies. A complex set of interactions between genes and other components of the expression system determine the amount of proteins produced from coding sequences. It is known that the elongation rate of polypeptide chain is affected by both codon usage bias and specific amino acid compositional constraints. Therefore, it is of interest to review local DNA-sequence elements and other positional as well as combinatorial constraints that play significant role in gene expression.
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spelling pubmed-74349572020-08-21 A report on DNA sequence determinants in gene expression Singh, Ravail Sophiarani, Yengkhom Bioinformation Research-Article The biased usage of nucleotides in coding sequence and its correlation with gene expression has been observed in several studies. A complex set of interactions between genes and other components of the expression system determine the amount of proteins produced from coding sequences. It is known that the elongation rate of polypeptide chain is affected by both codon usage bias and specific amino acid compositional constraints. Therefore, it is of interest to review local DNA-sequence elements and other positional as well as combinatorial constraints that play significant role in gene expression. Biomedical Informatics 2020-05-31 /pmc/articles/PMC7434957/ /pubmed/32831525 http://dx.doi.org/10.6026/97320630016422 Text en © 2020 Biomedical Informatics http://creativecommons.org/licenses/by/3.0/ This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research-Article
Singh, Ravail
Sophiarani, Yengkhom
A report on DNA sequence determinants in gene expression
title A report on DNA sequence determinants in gene expression
title_full A report on DNA sequence determinants in gene expression
title_fullStr A report on DNA sequence determinants in gene expression
title_full_unstemmed A report on DNA sequence determinants in gene expression
title_short A report on DNA sequence determinants in gene expression
title_sort report on dna sequence determinants in gene expression
topic Research-Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434957/
https://www.ncbi.nlm.nih.gov/pubmed/32831525
http://dx.doi.org/10.6026/97320630016422
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