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Effects of electrical stimulation‐induced resistance exercise training on white and brown adipose tissues and plasma meteorin‐like concentration in rats

Chronic endurance exercise training induces morphological and metabolic alterations including mitochondrial biogenesis in white adipose tissue (WAT) and brown adipose tissue (BAT) in rodents. A myokine called meteorin‐like (Metrnl) is associated with morphological and metabolic adaptation and increa...

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Autores principales: Amano, Yuhei, Nonaka, Yudai, Takeda, Reo, Kano, Yutaka, Hoshino, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435032/
https://www.ncbi.nlm.nih.gov/pubmed/32812347
http://dx.doi.org/10.14814/phy2.14540
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author Amano, Yuhei
Nonaka, Yudai
Takeda, Reo
Kano, Yutaka
Hoshino, Daisuke
author_facet Amano, Yuhei
Nonaka, Yudai
Takeda, Reo
Kano, Yutaka
Hoshino, Daisuke
author_sort Amano, Yuhei
collection PubMed
description Chronic endurance exercise training induces morphological and metabolic alterations including mitochondrial biogenesis in white adipose tissue (WAT) and brown adipose tissue (BAT) in rodents. A myokine called meteorin‐like (Metrnl) is associated with morphological and metabolic adaptation and increased in blood after acute resistance exercise. However, the effects of chronic resistance exercise training (RT), which aims to increase muscle mass and strength, on WAT and BAT are unclear. Therefore, we aimed to clarify the effects of RT on morphological and metabolic parameters in WAT and BAT and on plasma Metrnl concentrations. We applied electrical stimulation to both legs of rats as RT three times a week for 4 weeks. RT reduced adipocyte size in subcutaneous WAT but induced no changes in mitochondrial and thermogenesis proteins. In BAT, peroxisome proliferator‐activated receptor gamma coactivator‐1 alpha (PGC‐1α) protein levels and mitochondrial content markers were significantly higher in the RT group compared with the control group. A significant positive correlation was found between the expression of PGC‐1α in BAT and plasma Metrnl concentrations. These results suggest that plasma Metrnl is associated with PGC‐1α and mitochondrial biogenesis in BAT. This study describes a potential role of RT in preventing metabolic diseases via altering WAT and BAT and increasing plasma Mertnl concentrations.
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spelling pubmed-74350322020-08-20 Effects of electrical stimulation‐induced resistance exercise training on white and brown adipose tissues and plasma meteorin‐like concentration in rats Amano, Yuhei Nonaka, Yudai Takeda, Reo Kano, Yutaka Hoshino, Daisuke Physiol Rep Original Research Chronic endurance exercise training induces morphological and metabolic alterations including mitochondrial biogenesis in white adipose tissue (WAT) and brown adipose tissue (BAT) in rodents. A myokine called meteorin‐like (Metrnl) is associated with morphological and metabolic adaptation and increased in blood after acute resistance exercise. However, the effects of chronic resistance exercise training (RT), which aims to increase muscle mass and strength, on WAT and BAT are unclear. Therefore, we aimed to clarify the effects of RT on morphological and metabolic parameters in WAT and BAT and on plasma Metrnl concentrations. We applied electrical stimulation to both legs of rats as RT three times a week for 4 weeks. RT reduced adipocyte size in subcutaneous WAT but induced no changes in mitochondrial and thermogenesis proteins. In BAT, peroxisome proliferator‐activated receptor gamma coactivator‐1 alpha (PGC‐1α) protein levels and mitochondrial content markers were significantly higher in the RT group compared with the control group. A significant positive correlation was found between the expression of PGC‐1α in BAT and plasma Metrnl concentrations. These results suggest that plasma Metrnl is associated with PGC‐1α and mitochondrial biogenesis in BAT. This study describes a potential role of RT in preventing metabolic diseases via altering WAT and BAT and increasing plasma Mertnl concentrations. John Wiley and Sons Inc. 2020-08-18 /pmc/articles/PMC7435032/ /pubmed/32812347 http://dx.doi.org/10.14814/phy2.14540 Text en © 2020 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Amano, Yuhei
Nonaka, Yudai
Takeda, Reo
Kano, Yutaka
Hoshino, Daisuke
Effects of electrical stimulation‐induced resistance exercise training on white and brown adipose tissues and plasma meteorin‐like concentration in rats
title Effects of electrical stimulation‐induced resistance exercise training on white and brown adipose tissues and plasma meteorin‐like concentration in rats
title_full Effects of electrical stimulation‐induced resistance exercise training on white and brown adipose tissues and plasma meteorin‐like concentration in rats
title_fullStr Effects of electrical stimulation‐induced resistance exercise training on white and brown adipose tissues and plasma meteorin‐like concentration in rats
title_full_unstemmed Effects of electrical stimulation‐induced resistance exercise training on white and brown adipose tissues and plasma meteorin‐like concentration in rats
title_short Effects of electrical stimulation‐induced resistance exercise training on white and brown adipose tissues and plasma meteorin‐like concentration in rats
title_sort effects of electrical stimulation‐induced resistance exercise training on white and brown adipose tissues and plasma meteorin‐like concentration in rats
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435032/
https://www.ncbi.nlm.nih.gov/pubmed/32812347
http://dx.doi.org/10.14814/phy2.14540
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