BRD4 promotes metastatic potential in oral squamous cell carcinoma through the epigenetic regulation of the MMP2 gene

BACKGROUND: Oral squamous cell carcinoma (OSCC) has increased morbidity, and its high metastatic potential affects patient survival. Bromodomain containing 4 (BRD4) is a chromatin protein that associates with acetylated histone lysines and facilitates transcription. BRD4 has been implicated in cell...

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Detalles Bibliográficos
Autores principales: Yamamoto, Tatsuro, Hirosue, Akiyuki, Nakamoto, Masafumi, Yoshida, Ryoji, Sakata, Junki, Matsuoka, Yuichiro, Kawahara, Kenta, Nagao, Yuka, Nagata, Masashi, Takahashi, Nozomu, Hiraki, Akimitsu, Shinohara, Masanori, Nakao, Mitsuyoshi, Saitoh, Noriko, Nakayama, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435185/
https://www.ncbi.nlm.nih.gov/pubmed/32499570
http://dx.doi.org/10.1038/s41416-020-0907-6

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